نتایج جستجو برای: subinhibitory concentrations

تعداد نتایج: 306940  

2010
Jiazhang Qiu Dacheng Wang Hua Xiang Haihua Feng Youshuai Jiang Lijie Xia Jing Dong Jing Lu Lu Yu Xuming Deng

BACKGROUND Targeting bacterial virulence factors is now gaining interest as an alternative strategy to develop new types of anti-infective agents. It has been shown that thymol, when used at low concentrations, can inhibit the TSST-1 secretion in Staphylococcus aureus. However, there are no data on the effect of thymol on the production of other exotoxins (e.g., alpha-hemolysin and enterotoxins...

Journal: :Antimicrobial agents and chemotherapy 1999
M Brunner U Hollenstein S Delacher D Jäger R Schmid E Lackner A Georgopoulos H G Eichler M Müller

Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on ...

Journal: :The Journal of antimicrobial chemotherapy 2005
Stephen H Gillespie Shreya Basu Anne L Dickens Denise M O'Sullivan Timothy D McHugh

OBJECTIVES Fluoroquinolones have found a place in the management of mycobacterial diseases including tuberculosis. It has been previously shown that subinhibitory concentrations of quinolones increase the mutation rate in Escherichia coli and staphylococci. The purpose of this study is to extend this observation to mycobacteria and to quantify mutation rates. METHODS The mutation rate in Myco...

Journal: :Antimicrobial agents and chemotherapy 1984
A L Barry R N Jones

Six different gram-negative bacilli were serially transferred through subinhibitory concentrations of seven quinolone derivatives or related organic acids. A gradual, stepwise decrease in susceptibility was noted with all seven drugs, and the resistant cultures demonstrated a concomitant cross-resistance to the other drugs.

Journal: :Antimicrobial agents and chemotherapy 1979
L Daneo-Moore P Bourbeau R Weinstein D Carson

Addition of the antibiotic cerulenin to cultures lowered the minimal effective concentration of penicillin G or methicillin required to produce bacterial lysis and killing. This effect was most pronounced at subinhibitory antibiotic concentrations. Cerulenin had no significant effects on lysis or killing induced in the presence of D-cycloserine, fosfomycin, bacitracin, or vancomycin.

Journal: :Molecular cell 2010
Benjamin B Kaufmann Deborah T Hung

In this issue of Molecular Cell, Kohanski et al. (2010) demonstrate that even subinhibitory concentrations of bactericidal antibiotics result in the generation of reactive oxygen species, leading to an increase in mutation rate and the emergence of multidrug-resistant bacterial strains.

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