Background Allergen specific immunotherapy is an effective treatment of allergic rhinitis. It is most commonly administered as repeated subcutaneous injections or as a daily sublingual tablet during 3-5 years. In order to shorten the treatment duration previous studies have evaluated the use of intralymphatic injections (ILIT) with promising results. This study assesses safety and efficacy of I...

BACKGROUND A patient's knowledge of his/her allergic condition and treatment is a key factor in adherence and effectiveness. METHODS To assess patients' understanding of allergy and acceptance of allergen immunotherapy on the basis of (i) information given by their physician at the time of prescription and (ii) a new communication template viewed some months later, we performed an Internet-ba...

Summary Background. Pharmacotherapy and immunotherapy are the main treatment modalities for respiratory allergy. The aim of this paper has been to evaluate the efficacy and tolerability of subcutaneous and sublingual immunotherapy in association in allergic patients, and to demonstrate that the patients who have performed a second oral vaccination cycle after 4-5 years from the first subcutaneo...

Background Poorly documented self-reported drug allergy (DA) is a frequent problem in daily clinical practice and has a considerable impact on prescription choices. Atopy has been described as a risk factor for drug hypersensitivity (DH). The aim of this study was to better investigate the cases of suspicion of DH reported by patients undergoing subcutaneous allergen-specific immunotherapy (SCIT).

BACKGROUND Allergic rhinitis and asthma are important public health concerns, yet there is no consensus about the benefits and harms of allergen-specific immunotherapy to treat these conditions. We performed an umbrella review of systematic reviews summarizing the current evidence for the benefits and harms of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). METHODS We s...

Objective(s):Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods:BALB/c...

BACKGROUND Current practice guidelines state that protease-rich fungal and insect extracts can be combined when preparing immunotherapy vaccines, but data supporting the stability of allergens in these mixtures have not been reported. OBJECTIVE To determine the stabilities and compatibilities of Alternaria alternata and German cockroach allergens in mixtures with other high-protease fungal an...