نتایج جستجو برای: structural determinants
تعداد نتایج: 488731 فیلتر نتایج به سال:
Rapid progress in structural biology and whole-genome sequencing technology means that, for many protein families, structural and evolutionary information are readily available. Recent developments demonstrate how this information can be integrated to identify canonical determinants of protein structure and function. Among these determinants, those residues that are on protein surfaces are espe...
OBJECTIVE To explore possible associations between self-reported prevalence of catastrophic illnesses such as chronic renal failure, HIV/AIDS and cancer and a set of structural social determinants. METHODS Ecological study using data from the 2005 Population Census conducted by the National Administrative Department of Statistics (DANE), focusing on municipalities in the Colombian department ...
1. Abstract 2. Importance of retroviral genetic variation 3. Historic developments in understanding retroviral genetic variation and RT fidelity 4. Factors that influence retroviral mutation rates 4.1. Reverse transcription 4.2. Other viral proteins 4.3. Nucleotide pools, DNA repair, and mammalian DNA polymerases 4.4. RNA transcription 4.5. RNA modification 4.6. Antiviral nucleoside analogs 5. ...
Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal function are different from those of somatostatin. We studied the structural basis for cortistatin's distinct biological activities. As with SRIF-14, CST-14 does not show any preferred conformation in s...
We investigated how volumes of cerebrospinal fluid (CSF), grey matter (GM) and white matter (WM) varied with age, sex, small vessel disease and cardiovascular risk factors in the Rotterdam Scan Study. Participants (n=490; 60-90 years) were non-demented and 51.0% had hypertension, 4.9% had diabetes mellitus, 17.8% were current smoker and 54.0% were former smoker. We segmented brain MR-images int...
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