The natural killer T (NKT) cell ligand alpha-galactosylceramide (alpha-GalCer) exhibits profound antitumor activities in vivo that resemble interleukin (IL)-12-mediated antitumor activities. Because of these similarities between the activities of alpha-GalCer and IL-12, we investigated the involvement of IL-12 in the activation of NKT cells by alpha-GalCer. We first established, using purified ...

We compared integrin-mediated adhesion to extracellular matrix (ECM) components of cultured human melanocytes and 6 human melanoma cell lines with different metastatic capacities in nude mice. Cultured melanocytes and most melanoma cell lines adhered strongly to fibronectin (FN), whereas only highly metastatic cell lines adhered to laminin (LM), collagen type I (COI) and type IV (COIV). Adhesio...

A mean-field theory of the electrodynamics a turbulent fluid is formulated under assumption that molecular electric conductivity correlated with velocity fluctuation in (radial) direction, $\mathbf{g}$. It shown for such homogeneous fluids strong turbulence-induced field advection anti-parallel to $\mathbf{g}$ arises almost independently rotation. For rotating fluids, an extra $\alpha$ effect a...

We show that if $R$ is a ring with an arbitrary idempotent $e$ such that $eRe$ and $(1-e)R(1-e)$ are both strongly nil-clean rings‎, ‎then $R/J(R)$ is nil-clean‎. ‎In particular‎, ‎under certain additional circumstances‎, ‎$R$ is also nil-clean‎. ‎These results somewhat improves on achievements due to Diesl in J‎. ‎Algebra (2013) and to Koc{s}an-Wang-Zhou in J‎. ‎Pure Appl‎. ‎Algebra (2016)‎. ‎...

‎The largest class of hyperstructures is the one which satisfies the weak properties; these are called $H_{v}$-structures‎. ‎In this paper we introduce a special product of elements in $H_{v}$-group $H$ and define a new class of $H_{v}$-groups called strongly $H_{v}$-groups‎. ‎Then we show that in strongly $H_{v}$-groups $beta=beta^{ast}$‎. ‎Also we express $theta$-hyperoperation and investigat...

Let $$p\in [1,\infty ]$$ , $$q\in )$$ $$s\in \mathbb {Z}_+:=\mathbb {N}\cup \{0\}$$ $$\alpha \in {R}$$ and $$\beta (0,1)$$ . In this article, the authors first find a reasonable version $$\widetilde{I}_{\beta }$$ of (generalized) fractional integral $$I_{\beta on special John–Nirenberg–Campanato space via congruent cubes, $$JN_{(p,q,s)_{\alpha }}^{\textrm{con}}(\mathbb {R}^n)$$ which coincides ...

We examined the distribution of sialoglycoconjugates in the cerebellum of 9-week-old and 30-month-old rats using light microscopy and electron microscopy in combination with two lectins, Maackia amurensis lectin (MAL) for Sia(alpha)2-3Gal and Sambucus sieboldiana agglutinin (SSA) for Sia(alpha)2-6Gal. Each lectin showed characteristic staining patterns. In young adult rats, MAL stained a strong...

Melanoma is the most aggressive skin-cancer, showing high mortality at advanced stages. Platelet Derived Growth Factor Receptor-alpha (PDGFR-alpha) potently inhibits melanoma- and endothelium-proliferation and its expression is significantly reduced in melanoma-biopsies, suggesting that melanoma progression eliminates cells expressing PDGFR-alpha. In the present study transient overexpression o...

A stable HepG2 cell line harboring a human cholesterol 7 alpha-hydroxylase (CYP7A) minigene/luciferase reporter gene construct was selected for studying transcriptional regulation of CYP7A gene promoter. Insulin and phorbol 12-myristate-13-acetate (PMA) strongly repressed the promoter activity as measured with luciferase activity expressed in the cells. The promoter activity of the 5' progressi...