BACKGROUND Bioflavonoids are well known for their multi directional biologic activity including antidiabetic effect. It has been demonstrated that flavonoids can act as insulin secretagogue or insulin mimetic agents. OBJECTIVES This experimental study was designed in Arak University of Medical Sciences, Arak, Iran, to investigate the effects of biochanin A (a bioflavonoid) on fasting blood gl...

Rat islets encapsulated in alginate-polylysine membranes were implanted intraperitoneally into nonimmunosuppressed streptozocin-induced diabetic mice. Diabetes was reversed within 3 days, and the animals remained normoglycemic for up to 144 days, with a mean xenograft survival of 80 days. This was significantly greater than nonencapsulated islets, which functioned for <14 days. The graft surviv...

N-hydroxyethyl phthalimide (PE-I) was prepared by refluxing phthalic anhydride with ethanolamine. 3phthalimidoethyl substituted benzoic acids (PE-II) were prepared by refluxing N-hydroxyethyl phthalimide with substituted benzoic acids. The corresponding acid chlorides (PE-III) were condensed with benzilidine-4acetophenone derivatives to afford the 3-(phthalimidoethyl)-4-substituted cinnamoyl su...

Nerve ischemia, both acute and chronic, may contribute to diabetic neuropathies, but the pathogenesis remains obscure. The vulnerability of diabetic nerve to ischemia was assessed by ligating arteries of supply of rat sciatic nerve after 20 wk of streptozocin-induced diabetes. In the first 24 h after the arterial ligations, severe and more rapidly occurring clinicopathological abnormalities wer...

Several anticancer drugs have been added to the therapeutic armamentarium in recent years. Some of these agents are traditional drugs with a long history of use in human oncology. Increased sophistication in clinical trial design in veterinary oncology has allowed the incorporation of agents previously viewed as excessively toxic. Other agents have been developed more recently. This article sum...