a sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. in this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (ec), eudragit rs100 (rs), and eudragit s100 (s) were prepared by direct compression. the release behaviors were then studied in two co...

in the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in f1 (1:0.75), f2 (1:1), f3 (1:1.5),...

We consider the shape-topological control of a singularly perturbed variational inequality. The geometry-dependent state problem that we address in this paper concerns a heterogeneous medium with a micro-object (defect) and a macro-object (crack) modeled in two dimensions. The corresponding nonlinear optimization problem subject to inequality constraints at the crack is considered within a gene...

Methods of damage development analyses for various types of composite materials such as 3-D woven composite have not been established sufficiently because it is quite difficult to simulate the failure propagation. A FEM simulation of failure process of 3-D composite was executed by Mibayashi including the thermal residual stresses after the curing process, and the deformations and stresses calc...

Fracture toughness, critical strain energy release rate and critical stress intensity factor were determined for lathe-cut, spherical, admixed, and two atomized high-copper dental amalgams. At a loading rate of 0.005cm min -1 for 24-hour samples, the spherical amalgam had the highest resistance to unstable crack propagation. At a loading rate of 0.05 cm min -1 for both 24-hour and one-month sam...

This paper studies the application of an inverse methodology for problem solving in fracture mechanics using the finite element analysis. The method was applied to both detection of subsurface cracks and the study of propagating cracks. The procedure for detection of subsurface cracks uses a first order optimization analysis coupled with a penalty function to solve for the unknown geometric par...

advanced high strength steels (ahss) have recently attracted great attention because of their superior mechanical properties. a modern group of these steels, known as twinning induced plasticity (twip) steels, shows a unique combination of strength and ductility even at high rates of strain. in order to examine the functionality of such steels in dynamic loading conditions, their mechanical beh...