The liquid-gas operations in the stirred vessels can be a complex system to analyze because of the presence numerous parameters and operational conditions that effect its performance. Since the past decades, CFD analysis is gaining popularity and even replacing the need for extensive experimentation. The objective of this review is to establish the approaches and equations commonly used in CFD ...

This paper reports on the CFD study of macro-mixing process of Rushton turbine in stirred tank. The code for mixing calculation is developed in the commercial CFD code CFX4.3. Mixing process simulation on different calculation method, different turbulent model and different tracer adding and detecting position are calculated. The simulation is three-dimensional and the impeller region is explic...

Cell Culture Bioreactors Basic Types of Bioreactors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 Stirred Tank (Well Mixed) vs. Tubular Reactor (Plug Flow) . . . . . . . . . . . . . . . . . 3 Segregated Bioreactors (Dead Zone Present) Compartmentalized Bioreactors . . 4 Implication When Growth or Reaction Occurs in the Reactor . . . . . ....

This study demonstrates the applicability of pressurized stirred tank bioreactors for oxygen transfer enhancement in aerobic cultivation processes. The specific power input and the reactor pressure was employed as process variable. As model organism Escherichia coli, Arxula adeninivorans, Saccharomyces cerevisiae and Corynebacterium glutamicum were cultivated to high cell densities. By applying...

The turbulent flow field generated in a baffled stirred tank was computed by large eddy simulation (LED) and the flow field was developed using the Sliding Mesh (SM) approach. In this CFD study, mixing times and power number have been determined for a vessel agitated by a 6-blade Rushton turbine. The predicted results were compared with the published experimental data. The satisfactory results ...