introduction: the use of stereological methods in evaluation of volume changes in vital organs such as kidney is very important. in this study, the volume of glomeruli in glycerol-induced acute renal failure in rats was determined. methods: 48 sprague-dawley male rats were divided into 2 groups (1control, 1experiment). experimental group was injected 10ml/kg of 50% glycerol intramuscularly, whi...

The unbiased sampling techniques of stereology have been developed to avoid the inaccuracies of using 'representative' sections for morphometric studies. In order to carry out a stereologically valid study, the region of interest must be fully available for sampling and its boundaries or its constituents must also be distinctly identifiable. However, in the setting of a brain bank in which only...

The non-human primate is an important translational species for understanding the normal function and disease processes of the human brain. Unbiased stereology, the method accepted as state-of-the-art for quantification of biological objects in tissue sections, generates reliable structural data for biological features in the mammalian brain. The key components of the approach are unbiased (sys...

Although the human eye is excellent for pattern recognition, it often lacks the sensitivity to detect subtle changes in particle density. Because of this, quantitative evaluation may be required in some studies. A common type of quantitative assessment used for routine toxicology studies is two-dimensional histomorphometry. Although this technique can provide additional information about the ti...

the aim of the present study was stereological evaluation of testes of azoospermic animal model using busulfan in rat. three groups of male adult rats were used in this study. the first group was injected by single dose of busulfan (10 mg kg-1) and their testes were removed on day 35 post injection. the second group received double doses of busulfan with 21 days interval and their testes were r...