10.1083/jcb.1727rr3jcb.1727rr3William A. [email protected] receptor activation T he FGF receptor gets its multiple phosphorylations not randomly but in a strictly ordered sequence, say Cristina Furdul, Erin Lew, Joseph Schlessinger, and Karen Anderson (Yale University, New Haven, CT). The intermediate phosphorylation states—neither ful...

Given data y and k covariates x one problem in linear regression is to decide which in any of the covariates to include when regressing y on the x. If k is small it is possible to evaluate each subset of the x. If however k is large then some other procedure must be use. Stepwise regression and the lasso are two such procedures but they both assume a linear model with error term. A different ap...

We analyze the optimal investment strategy of a firm that can complete a project either in one stage at a single freely chosen time point or in incremental steps at distinct time points. The presence of economies of scale gives rise to the following trade-off: lumpy investment has a lower total cost, but stepwise investment gives more flexibility by letting the firm choose the timing individual...

In this paper, rigorous application of stepwise refinement is explored. The steps of definition, decomposition, and completion are described, where completion is a newly introduced step. This combination of steps extends the use of stepwise refinement to larger systems. The notions of range, active objects, and backlog interface are introduced. Verification of incomplete programs via interactiv...

Androgen-regulated gene expression is a highly coordinated dynamic process mediated by androgen receptor (AR) ligand binding and DNA binding, and by specific AR protein-protein interactions. The latter include DNA-binding domain (D-box) interactions in AR homodimers, and the interaction of the FQNLF motif in the AR N-terminal domain and the coactivator groove in the ligand-binding domain (N/C i...

introduction: it has been shown that joint click, an initial and common finding in internal derangement (id), respond to neither conservative treatment nor surgical intervention. this raises the question as to whether it must be treated in the absence of other pertinent signs and symptoms, so the aim of this study was to investigate and compare the mri findings of tmj in both normal subjects an...

Abstract Materials with a mechanical response to an external stimulus are promising for application in miniaturized cargo and fluid manipulation microfluidic (lab-on-a-chip) systems microsystems general. One of the main challenges droplet microfluidics is precise control motion, existing technologies have drawbacks that can compromise contents. Here, we demonstrate how on–off switchable ratchet...

abstract for seismic design, it is important to estimate the, maximum lateral displacement (inelastic displacement) of the structures due to earthquakes for several reasons. seismic design provisions estimate the maximum roof and storey drifts occurring in major earthquakes by amplifying the roof displacement and drifts of the structures obtained by elastic analysis subjected to seismic design ...