We present a calculation of the pion quark momentum fraction, $?x?$, and its third Mellin moment $?{x}^{2}?$. also obtain directly, for first time, $?x?$ $?{x}^{2}?$ kaon using local operators. use an ensemble two degenerate light, strange, charm (${N}_{f}=2+1+1$) maximally twisted mass fermions with clover improvement. The masses are chosen so that they reproduce about 260 MeV 530 MeV. lattice...

Peribronchiolar fibrosis is a prominent feature of airway remodeling in asthma and involves fibroblast growth and collagen deposition. Interleukin-13 (IL-13), a T-helper 2 cytokine, is a key mediator of airway remodeling in asthma, yet the mechanism through which IL-13 promotes fibroblast growth has not been investigated. In this study, we show that IL-13 stimulates the mitogenesis of mouse, ra...

Transcriptional responses to the activation of a signalling pathway are cell-specific. New data show that the sequence-specific transcriptional repressors of the KEN/BCL-6 family play an important role in the selection of STAT targets in vertebrates and invertebrates, indicating that all STAT proteins may share this ancestral mechanism.

Naturally occurring regulatory T (nTreg) cells express Foxp3 and were originally discovered as immune suppressors critical for self-tolerance and immune homeostasis. Through yet-to-be-defined mechanisms, nTreg cells were recently shown to convert into proinflammatory cells. Particularly, attenuation of Foxp3 expression led to Th2 conversion of nTreg cells in vivo. In this paper, we demonstrated...

We present a calculation of the pion quark momentum fraction, $⟨x⟩$, and its third Mellin moment $⟨{x}^{2}⟩$. also obtain directly, for first time, $⟨x⟩$ $⟨{x}^{2}⟩$ kaon using local operators. use an ensemble two degenerate light, strange, charm (${N}_{f}=2+1+1$) maximally twisted mass fermions with clover improvement. The masses are chosen so that they reproduce about 260 MeV 530 MeV. lattice...

Suppressor of cytokine signaling-1 (SOCS-1) is one of the negative-feedback regulators of Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling. We previously showed that SOCS-1 participates in LPS signaling, but it is not entirely clear yet how SOCS-1 suppresses LPS signaling. In this study, we demonstrate that SOCS-1 selectively inhibits LPS-induced IL-6 product...