According to the 2010 WHO classification of digestive system tumors, esophageal low‐grade intraepithelial neoplasia (LGIEN) is associated with ultrastructural and cytological abnormalities confined to the lower half of the epithelium, and squamous cell carcinoma (SCC) is defined as tumor invasion of the lamina propria or penetration into deeper tissue layers. We here reported a rare esophageal ...

Bowen's disease, also known as an intraepithelial squamous cell neoplasia, is a carcinoma in situ firstly reported in 1912 by a dermatologist named Bowen from the United States [1]. About 3%~5% of Bowen's disease might develop into invasive squamous cell carcinomas of mocusa and skin [2]. Surgical resection is preferred because of its low recurrence. Here we reported a rare Bowen's disease case...

Vulvar tumors are not very common and account for about 4% of all cancers affecting the female genital organs. Frequently, malignant neoplasia of this site have squamous phenotype and the rare cases of metastasization are reported in the locoregional lymph nodes and in the surrounding organs. We report a case of metastasization of a vulvar squamous cell carcinoma in an unusual place such as the...

The aim of this study was to reveal whether 3 biomarkers (p16INK4a, ProEx C, and human papilloma virus DNA) are useful in the diagnosis of cervical intraepithelial neoplasia and whether they could predict disease progression of cervical intraepithelial neoplasia-1. We analyzed 252 cervical specimens: nondysplastic mucosa (n = 9), cervical intraepithelial neoplasia (n = 229), and squamous cell c...

Synchronous second primary tumors (SPTs), especially esophageal squamous cell neoplasia (ESCN), in patients with head and neck squamous cell carcinoma (HNSCC) are not uncommon. Image-enhanced endoscopy (IEE) screening may identify SPTs while there is no evidence to support its benefit. We prospectively recruited an adult cohort with newly-diagnosed HNSCC for IEE screening of upper gastrointesti...

AIM To describe the use of a new spatulated cryoprobe in treatment of conjunctival neoplasia. METHODS A new cryoprobe design was submitted to Mira, Inc resulting in new hand held probes capable of producing homogeneous freezing over large surface areas. The active surface of the small, medium, and large spatulated probes are 8.5 mm2, 25.2 mm2, and 70 mm2. End freezing reduces the possibility ...

Received July 2009 Accepted January 2010 INTRODUCTION Renal pelvis is normally lined by urothelium and contains neither squamous nor intestinal epithelium. However, transitional cell epithelium undergoes phenotypic changes usually in the form of squamous metaplasia.(1) We report a rare case of intestinal metaplasia of the renal pelvis with cytokeratin profile and assessment of the tumor markers...

In the last years, the prevalence of HPV infection in the anal region has increased, especially in some groups like homosexual and HIV-positive people. Since this infection can be associated with the development of squamous anal cancer due to its progression from HPV infection to anal intraepithelial neoplasia (AIN) and finally to cancer, the screening and evaluation of these conditions are imp...

Nonneoplastic and neoplastic cervical biopsy specimens were examined by in situ hybridization to 125I-labeled DNA of herpes simplex virus (HSV), adenovirus, and bacteriophage lambda DNA's, and quantitative hybridization data were obtained using a Video Image Analyser. HSV-specific RNA was detected in 72% of cervical intraepithelial neoplasia, 60% of squamous cervical carcinomas, 2% of nonneopla...

OBJECTIVE Cervical carcinoma is an important women's health problem in the Western countries. There are only few published data on this disease in the Kingdom of Saudi Arabia (KSA). The aim of this study is to evaluate the abnormal cytological entities detected by cervical Pap smear in Western region of KSA and to discuss the importance of Pap smears screening programs. METHODS Retrospective ...