background and objective: hypothyroidism is a known consequence of the external beam radiotherapy to the neck encompassing the thyroid gland for over 40 years. the aim of this study was to find out the incidence of hypothyroidism in patients with head and neck cancer treated with radiotherapy, when radiation portals included whole of the thyroid gland. materials and methods: this prospective no...

The head and neck region consists of subsites, including the oral cavity, pharynx, larynx, nasal sinuses, salivary glands, and orbits, and contains important organs performing functions that are directly related to the Quality of Life (QOL), such as chewing, swallowing, and phonation. It has been reported that 32% of head and neck cancers occur in the oral cavity, 24% in the larynx, 35% in the ...

The care of head and neck squamous cell carcinoma has greatly evolved over the past 30 years. From single modality to a multidisciplinary care, there has also been a concurrent increase in treatment intensity, resulting, at many times, in more zealous regimens that patients must endure. In this article, we apply Porter's value model as a framework to balance survival, toxicities, cost, and trad...

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world and affects 50,000 Americans annually. During the past 20 years, treatments for HNSCC have changed dramatically due largely to the advent of novel approaches such as combined modality therapy, as well as improvements in surgical and radiotherapeutic techniques. Ongoing advances in the multidisciplinary ma...

Introduction HPV as a risk factor of head and neck squamous cell carcinoma (HNSCC) is gaining increasing importance. Tobacco alcohol abuse already known to induce the occurrence HNSCC. However, awareness an independent vaccination preventive measure not widespread among general population.

Despite the use ofmultimodality therapy using cisplatin to treat patientswith advanced stage squamous cell carcinoma of the head and neck (HNSCC), there is an unacceptably high rate of treatment failure. TP53 is the most commonlymutated gene inHNSCC, and the impact of p53mutation on response to cisplatin treatment is poorly understood. Here, we show unambiguously that wild-type TP53 (wtp53) is ...

For citation purposes: Lanzer M, Zemann W, Lübbers T, Kruse A, Reinisch S. Do patients with oral and oropharyngeal squamous cell carcinoma benefit from elective contralateral neck dissection? A long-term analysis. Head Neck Oncol. 2012 Oct 31;4(3):70. Licensee OA Publishing London 2012. Creative Commons Attribution License (CC-BY) Abstract Objectives Oral and oropharyngeal squamous cell carcino...

Head and neck cancer (HNC) is a common malignant tumor, but traditional therapeutic methods have unsatisfactory curative effects and many complications occur. Hence, there is an urgent need to develop therapeutic methods that can elicit curative effects as well as low toxic and few side effects. With the development of cancer molecular biology and immunology, targeted therapy for immune checkpo...