Estrogens are major risk factors for the development of breast cancer; they can be metabolized to catechols, which are further oxidized to DNA-reactive quinones and semiquinones (SQs). These metabolites are mutagenic and may contribute to the carcinogenic activity of estrogens. Redox cycling of the SQs and subsequent generation of reactive oxygen species (ROS) is also an important mechanism lea...

In this note, we show that the variety of semi-Boolean SQS-skeins can be defined by a single axiom and exhibit a single axiom for said variety that was found with the aid of the automated theorem-prover Prover9.

Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The golden carotenoid pigment of S. aureus, staphyloxanthin, promotes resistance to reactive oxygen species and host neutrophil-based killing, and early enzymatic steps in staphyloxanthin production resemble those for cholesterol biosynthesis. W...

The notational analysis is used to investigate teams' performance in water polo, especially focused on the determinants of success. Recently, a new topic has emerged "the situational variables," which includes the game conditions that may influence the performance at a behavioral level. The aim of this study was to identify the interactive effects of starting quarter score (SQS) (i.e., score di...

We compare the asymptotic covariance matrix of the ML estimator in a nonlinear measurement error model to the asymptotic covariance matrices of the CS and SQS estimators studied in Kukush et al (2002). For small measurement error variances they are equal up to the order of the measurement error variance and thus nearly equally efficient.

We discuss two different nonlinear generalizations of the osp(2|2) supersymmetry which arise in superconformal mechanics and fermion-monopole models. Submitted to the Proceedings of the International Workshop “Supersymmetries and Quantum Symmetries” (SQS’03, Dubna, Russia, 24-29 July 2003)

In diesem Papier werden Erfahrungen aus gemeinsamen Projekten des Kunden und der SQS bei der Durchführung proaktiver Qualitätssicherungsmaßnahmen im Umfeld von eingebetteten Telekommunikationssystemen erläutert. Dabei werden insbesondere die Vorteile von frühzeitig ergreifbaren Qualitätssicherungsmaßnahmen mit Hilfe statischer Code-Analysewerkzeuge sowie deren ungefähre Quantifizierung erkennbar.

(1) Hospital Regional da Asa Norte, Secretaria de Saúde do Distrito Federal, SMHN, AE 1, Bloco A, 70000-000, Brasília, DF, Brasil. (2) Núcleo de Medicina Tropical, Universidade de Brasília, Brasília, DF, Brasil. Corresponence to: Jefferson Lessa Soares de Macedo, SQS 213 Bloco ‘H’ Apto. 104, Asa Sul, 70292-080 Brasília, DF, Brasil. E-mail: [email protected] PREDICTIVE FACTORS OF MORTALITY ...

Squalene synthase (SQS; EC 2.5.1.21) plays an important role in the cholesterol biosynthetic pathway. We discovered ER-28448, 5-(N-[2-butenyl-3-(2-methoxyphenyl)]-N-methylamino)-1, 1-penthylidenebis(phosphonic acid) trisodium salt, as a potent and selective inhibitor of SQS. ER-28448 inhibited SQS in rat liver microsome with an IC(50) value of 3.6 nm. We also prepared ER-27856, the tripivaloylo...