In This Issue In This Issue Saying NO to muscular dystrophy ccording to the prevailing model for Duchenne muscular dystrophy (DMD) pathogenesis, a lack of dystrophin protein makes muscle cells susceptible to mechanical damage, leading to muscle breakdown. On page 123, Wehling et al. suggest that the major damage in DMD may actually be caused by a secondary consequence of dystrophin loss: destru...

Abnormally high levels of spontaneous and mitomycin C or diepoxybutane induced chromosome breakage were observed in lymphocytes from eight out of nine previously undescribed patients clinically diagnosed as having Fanconi's anaemia. The results suggest that the combination of spontaneous and induced chromosome breakage is a good aid in the differential diagnosis and we suggest that increased ch...

Literature dealing with the mechanisms of hair breakage in combing and brushing published so far has been reviewed as a background for the critical evaluation of the method and data analysis of the paper “Statistical Analysis of Hair Breakage. II” by Evans and Park (1). Accumulated knowledge about hair breakage in these grooming processes indicates that hair breakage in combing and brushing res...

BACKGROUND There are multiple techniques to approach the glenohumeral joint. Our purpose was to quantify the average area of the glenohumeral joint exposed with 3 subscapularis approaches and determine the least invasive approach for placement of shoulder resurfacing and total shoulder arthroplasty instruments. METHODS Ten forequarter cadaveric specimens were used. Subscapularis approaches we...

the effective factors of forward speed, cylinder rotation, and clearance between a combine’s cylinder and concave on wheat kernel breakage and seed germination were studied in karaj area using a 955 model john dear combine. this study was conducted on three levels of adjustment for each of the variables, 1.2, 1.8 and 2.5 km/hr for forward speed, 800, 900, 1000 rpm for cylinder rotation as well ...

INTRODUCTION Split tendon transfer of the tibialis posterior (SPOTT) is commonly performed to correct hindfoot varus in patients with cerebral palsy, stroke, and brain injury. The original SPOTT procedure has been previously shown to alter the action at the subtalar joint but not at the talocrural joint [1]. This procedure involves the longitudinal splitting of the distal tibialis posterior (TP...

The Nijmegen breakage syndrome is a rare autosomal recessive chromosomal instability disorder characterized by early growth retardation, congenital microcephaly, immunodeficiency, borderline mental development, and a high tendency to lymphoreticular malignancies. Most Nijmegen breakage syndrome patients are of Slavonic origin, and all of them known so far carry a founder homozygous 5 nucleotide...

Chromosome breakage as a result of replication stress has been hypothesized to be the direct consequence of defective replication fork progression, or "collapsed" replication forks. However, direct and genome-wide evidence that collapsed replication forks give rise to chromosome breakage is still lacking. Previously we showed that a yeast replication checkpoint mutant mec1-1, after transient ex...

It has been observed that the pattern of particle impact breakage in two-dimensional systems is a result of two mechanisms. AMechanism IB accounts for the breakage induced by the stresses that appear in unbroken particles. AMechanism IIB breakage is due to the buckling of the Mechanism I fragments. The purpose of this paper is to try and understand the parameters that govern the magnitude of th...