Several studies have shown the occurrence of Periodic Leg Movement (PLM) in spinal cord injury patients. The aim of this study was to identify the occurrence of limb movements during sleep in spinal cord injury rats and the possible involvement of the spinal cord in causing these movements. The animals were allocated to spinal cord injury (SCI) and SHAM groups. The two groups were submitted to ...

iv Table of contents vi List of illustrations xi List of abbreviations xiv Chapter 1 --Introduction 1.1. Spinal cord injury induces chronic pain 1 1.2. Neurobiology of neuropathic pain 2 1.3. Multiple sites are altered after SCI, including DRG 5 1.4. Hyperexcitability of primary nociceptors appears to be an important mechanism underlying chronic pain after SCI 8 1.5. TRPV1 in nociceptors is pot...

Spinal cord injury (SCI) is characterized by damage resulting in dysfunction of the spinal cord. Hydrogels are common biomaterials that play an important role treatment SCI. biocompatible, and some have electrical conductivity compatible with tissues. a high drug-carrying capacity, allowing them to be used for SCI through loading various types active substances, drugs, or cells. We first discus...

Background: Urodynamics is the gold standard for evaluating function of neurogenic bladder after spinal cord injury (SCI), but there are few studies on urodynamics in patients with complete and incomplete suprasacral SCI different periods.There a lack sufficient evidence timing first urodynamic examination.

BACKGROUND Spinal cord injury (SCI) is one of the most devastating conditions leading to neurological impairment and disabilities. The aim of the study was to investigate the potential neuroprotective effect of thymoquinone (TQ) histopathologically in an experimental model of traumatic spinal cord injury (SCI). METHODS Twenty-four male Wistar albino rats were randomly divided into 4 groups: c...

objective: to determine the effects of recombinant human erythropoietin (rhepo) on functional outcome and disability of patients with traumatic cervical spinal cord injury (sci).  methods: this was a randomized, double blind, placebo controlled clinical trial being performed in nemazee and shahid rajaei hospitals of shiraz during a 3-year period from 2011 to 2014. a total number of 20 patients ...

Objective(s):Spinal cord injury (SCI) is one of the most serious clinical diseases and its treatment has been a subject of interest to researchers. There are two important therapeutic strategies in the treatment of SCI: replacing lost tissue cells through cells implantation and scar elimination. Therefore, in this study we used human adipose-derived stem cells (hADSCs) implantation and injectio...

Spinal cord injury (SCI) is an irreversible disease resulting in partial or total loss of sensory and motor function. The pathophysiology SCI characterized by initial primary phase followed a secondary which reactive oxygen species (ROSs) associated oxidative stress play hallmark roles. Physical exercise indispensable means promoting psychophysical well-being improving quality life. It positive...

Spinal cord injury (SCI) is well known as a severely disabling that can result in long-term neurological impairment and great impact on the social economic aspects of patients. To investigate controversy regarding Stem Cell Transplantation treatment modality to alleviate devastating effect Cord Injury, we performed literature research according PRISMA guidelines through Pubmed, Cochrane, EMBASE...

spinal cord injury (sci) is a destructive event that often lead to permanent neurologic deficit. current clinical treatments are aimed at preventing secondary damage, promoting regeneration, and replacing destroyed spinal cord tissue, although effective treatments for sci remain limited. cell therapies for treating sci are promising therapy for replacing dead cells, neuroprotection and axon reg...