polyphenols have been shown to have some of the neuroprotective effects against neurodegenerative diseases. these effects are attributed to a variety of biological activities, including free radical scavenging/antioxidant and anti-inflammatory and anti-apoptotic activities. in this regard, many efforts have been made to study the effects of various well-known dietary polyphenols on spinal cord ...

Stressful events like severe illnesses and injuries impact self-experience. This study investigates the identity characteristics of people with schizophrenia and those following spinal cord injury. 30 participants from each group and members of the control group answered the Tennessee Self-Concept Scale and evaluated themselves on a semantic differential. The results indicate a confused identit...

The increased rate of fracture healing and abundant callus formation of long bone fractures in patients with concomitant severe acute traumatic head injury is a well-known orthopedic phenomenon, Few studies, however, have reported these phenomena being induced by acute traumatic Spinal Cord Injury (SCI). There is also a well-established clinical relationship between spinal cord injuries and het...

With technological advances in basic research, the intricate mechanism of secondary delayed spinal cord injury (SCI) continues to unravel at a rapid pace. However, despite our deeper understanding of the molecular changes occurring after initial insult to the spinal cord, the cure for paralysis remains elusive. Current treatment of SCI is limited to early administration of high dose steroids to...

Clinically-relevant animal cervical spinal cord injury (SCI) models are essential for developing and testing potential therapies; however, producing reliable cervical SCI is difficult due to lack of satisfactory methods of vertebral stabilization. The conventional method to stabilize the spine is to suspend the rostral and caudal cervical spine via clamps attached to cervical spinous processes....

Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...

Introduction: Spinal cord injuries (SCI) lead to permanent irreversible functional deficits.  Poor prognosis of patients is the motivation of searching a treatment for the chronic injury.  Planting stem cells provides us with a promising strategy. In the meanwhile, the use of olfactory ensheathing cells (OECs) has shown very good results.  This study aims at evaluating the effe...

Compound action potential (CAP) of spinal cord represents valuable properties of neural fibers including excitability, rate of myelination and membrane integrity. These properties are measured using amplitude, latency and area under curve of CAPs recorded from spinal cord. Here, the isolated spinal cord was set in a double sucrose gap (DSG) chamber and its response to intracellular stimulation ...

Both real action control and execution and motor imagery abilities require knowledge of the spatial location of body parts, in other words efference copy information and feedbacks from the sensory system (Frith et al., 2000, Philos. Trans. R. Soc. Lond. B. Biol. Sci., 355, 1771). Spinal cord injuries induce severe motor disability, due to a damage of the descending motor pathways (Cramer et al....

Association between difficult delivery and spinal cord injury (SCI) at birth has been known since 1870(1). Majority of such injuries are seen following difficult breech extractions but SCI in cephalic deliveries are rare(2). With the improvement in obstetrical care, SCI have become rare and often uncertainty about its diagnosis exists during the early postnatal period. We report two cases of SC...