INTRODUCTION Detection of drug-induced pro-arrhythmic risk is a primary concern for pharmaceutical companies and regulators. Increased risk is linked to prolongation of the QT interval on the body surface ECG. Recent studies have shown that multiple ion channel interactions can be required to predict changes in ventricular repolarisation and therefore QT intervals. In this study we attempt to p...

Demand of gelatin for food and pharmaceutical application is increasing because it is one of the most widely used food ingredients. Fish gelatin represents one of the important types of gelatin from other sources other than mammalian gelatins and it may thus be considered as an alternative to mammalian gelatin for use in various food and pharmaceutical applications. The main objective of the st...

Naïve humans and rats voluntarily consume little ethanol at concentrations above ~6% due to its aversive flavor. Developing procedures that boost intake of ethanol or ethanol-paired flavors facilitates research on neural mechanisms of ethanol-associated behaviors and helps identify variables that modulate ethanol intake outside of the lab. The present study explored the impact on consumption of...

Eleven morphometric variables including weight were recorded for 429 specimens of obtuse barracuda Sphyraena obtusata Cuvier, 1829 collected over a period two years from January 2017 to December 2018, Vizhinjam fish landing centre, Thiruvananthapuram, Kerala. Length-weight relationship and length-length the species estimated using linear regression analysis. Different length measurements conver...

Ciguatera in humans is typically caused by the consumption of reef fish that have accumulated Ciguatoxins (CTXs) in their flesh. Over a six month period, we captured 38 wild adult great barracuda (Sphyraena barracuda), a species commonly associated with ciguatera in The Bahamas. We sampled three tissues (i.e., muscle, liver, and blood) and analysed them for the presence of ciguatoxins using a f...

Aim: The present study was conducted to investigate the fishery, diet composition and reproductive aspects of obtuse barracuda landed in Karnataka, south-west coast India. Methodology: Feeding traits 1229 samples (638 males 591 females) S. obtusata studied for a period five years. index relative importance (IRI) determined each component stomach. Reproductive such as maturity stages, gonadosoma...