The membrane biofilm reactor (MBfR) a novel bioreactor that provides gaseous substrates directly to a biofilm growing on the membrane surface, avoiding the need for sparging. MBfRs are not membrane bioreactors (MBRs), where membranes separate suspended solids from the effluent water, substituting for a clarifier. In MBfRs, a gaseous substrate moves across the membrane. Since the MBfR membranes ...

Increasing the throughput and efficiency of cell culture process development has become increasingly important to rapidly screen and optimize cell culture media and process parameters. This study describes the application of a miniaturized bioreactor system as a scaled-down model for cell culture process development using a CHO cell line expressing a recombinant protein. The microbioreactor sys...

Agitated bacterial tank bioleaching reactors are currently sparged with air to satisfy both oxygen and CO(2) requirements of microbial cells. Under high-sulphide loading conditions, as is the case with high-grade metal sulphide concentrates, the microbial and chemical demand for oxygen is significantly increased during the bioleaching process. Sparging with enriched oxygen gas may offer an alte...