Study Design In vitro biomechanical investigation. Purpose To compare the biomechanics of integrated three-screw and four-screw anterior interbody spacer devices and traditional techniques for treatment of degenerative disc disease. Overview of Literature Biomechanical literature describes investigations of operative techniques and integrated devices with four dual-stacked, diverging interb...

Simultaneous prosthetic joint infection of ipsilateral hip and knee arthroplasties is often accompanied by significant bone loss and presents a challenging reconstructive problem. Two-stage reconstruction is favored and requires the placement of a total femur spacer, which is not a commercially available device. We describe a surgical technique, reporting on 2 cases in which a customized total ...

Computational fluid dynamics (CFD) simulations carried out in this paper show that spacer orientation has a major influence on temperature patterns and on the heat transfer rates. The local heat flux values significantly vary from high to very low values at each filament when spacer touches the membrane surface. The heat flux profile is more uniform when spacer filaments are not in contact with...

Impact of high-κ spacer in Asymmetric underlap double gate MOS transistor is systematically investigated with the help of a two dimensional device simulator. A significant improvement in ON current, transconductance and intrinsic gain is observed in the device using high-κ spacer material. However due to higher capacitances, device with high-κ spacer shows smaller unity gain cut-off frequency c...

BACKGROUND A practitioner questioned whether moisture that collected in the ventilator circuit and spacer affected the delivery of aerosol from a pressurized metered-dose inhaler (pMDI). An in vitro model was used to quantify the impact of accumulated humidity in a pMDI spacer and ventilator over time. METHODS A ventilator with an adult heated-wire ventilator circuit and humidifier was set to...

In magnetic multilayers, the magnetizations of two ferromagnetic layers separated by a non-magnetic spacer layer are coupled by the electrons in the spacer layer. This coupling oscillates in sign as a function of the thickness of the spacer layer. Extensive research done on these systems has led to a simple model for this coupling and remarkable agreement between predictions of the model and me...

Nuclear factor I (NFI) is a site-specific DNA binding protein required for the replication of adenovirus type 2 DNA in vitro and in vivo. To study sequence requirements for the interaction of NFI with DNA, we have measured the binding of the protein to a variety of synthetic sites. Binding sites for NFI (FIB sites) were previously shown to contain a consensus sequence composed of 2 motifs, TGG ...

Rare individuals of Xenopus laevis exhibit frequent initiation of transcription in the spacers of oocyte ribosomal DNA (rDNA). Using electron microscopy we have characterized spacer transcription in such an individual and have confirmed that the sites of transcription initiation correspond to the imperfectly duplicated promoters ("Bam islands") present in the X. laevis rDNA spacer. We have clon...