This paper builds on and extends U.S. Department of Defense published guidance on systems engineering (SE) of systems of systems (SoS) by developing and presenting a view of SoS SE that translates the SoS SE core elements, their interrelationships, and SoS decision-making artifacts and information from a “trapeze” model to a more familiar and intuitive time-sequenced “wave” model representation...

We present and evaluate the SOS chromotest, a bacterial test for detecting DNA-damaging agents. It is a colorimetric assay based on the induction by these agents of the SOS function sfiA, whose level of expression is monitored by means of a sfiA::lacZ operon fusion. The response is rapid (a few hours), and does not require survival of the tester strain. Dose-response curves for various chemical...

PURPOSE Imaging features of sinusoidal obstruction syndrome (SOS), an increasingly common drawback of chemotherapy, were evaluated via 18F-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET/CT). EXPERIMENTAL DESIGN This retrospective study was approved by our Institutional Review Board, with a waiver of informed consent. FDG PET/CT studies of 35 patients (male, 24;...

Many systems of systems (SoS) occur today through the collaboration of multiple stakeholders, without any clear authority or direction at the SoS level. Examples include a supply chain, an airport, and the Internet. Because of the uncontrolled interactions, such a SoS exhibits complexity behaviors such as reflexivity, emergence, self-organization, and adaptation. This paper presents underlying ...

The SANY IP consortium (http://www.sany-ip.eu) has recently developed several interesting service prototypes that extend the usability of the Open Geospatial Consortium "Sensor Web Enablement" (OGC SWE) architecture. One such service prototype, developed by the Austrian Research Centers, is the "cascading SOS" (SOS-X). SOS-X is a client to the underlying OGC Sensor Observation service(s) (SOS)....

Model Based Systems Engineering (MBSE) follows a model centric approach in contrast to the traditional document centric approach. The complexity of SoS development lends itself nicely to a model centric approach, especially a model that can represent the independence of the systems that comprise the SoS. An agent-based model provides a framework where the SoS and each system are independent ent...

In this exploratory work, an integrated systems engineering methodology for analyzing architectures of systems of systems (SoS) involves linking an SoS architecture development process to the DoDAF products, using the systems modeling language (SySML 1.0) to represent DoDAF products, and hence to model the SoS architecture, and linking the SysML diagrams with the SoS architecture development pr...

Sos proteins are ubiquitously expressed activators of Ras. Lymphoid cells also express RasGRP1, another Ras activator. Sos and RasGRP1 are thought to cooperatively control full Ras activation upon T-cell receptor triggering. Using RNA interference, we evaluated whether this mechanism operates in primary human T cells. We found that T-cell antigen receptor (TCR)-mediated Erk activation requires ...

Systems of Systems (SoS) have received a lot of attention recently. In this thesis we will focus on SoS that are built atop the techniques of Service-Oriented Architectures and thus combine the benefits and challenges of both paradigms. For this thesis we will understand SoS as ensembles of single autonomous systems that are integrated to a larger system, the SoS. The interesting fact about the...

Ensuring resilience – the ability to remain dependable in dynamic environment – constitutes a major challenge for engineering systems-of-systems (SoS). In this paper, we take a mission-centric view on the behaviour of SoS and demonstrate how to formally reason about their dependability. We use Event-B as our modelling framework and demonstrate how to formally specify and verify generic system-w...