The calmodulin and calcium dependence of human adenylate cyclase from the second part of the duodenum was assessed in washed particulate preparations of biopsy specimens by investigating (a) the concentration dependent effects of free [Ca2+] on enzyme activity, (b) the effects of exogenous calmodulin on enzyme activity in ethylene glycol bis (b-aminoethyl ether)N,N'-tetra-acetic acid (EGTA) was...

The importance of fluoride as a natural and industrial toxicant is recognized worldwide. We evaluated the regulating role and biological effect of vesicular (liposomal and nanoencapsulated) melatonin (N-acetyl-5-methoxytryptamine) for drug delivery and controlled release on the depletion of inflammatory mediators, as well as oxidative damage in sodium fluoride (NaF)-treated lungs and liver. Hep...

Aim. The aim of this study was to compare the effect of pH cycling on the microhardness of the enamel of primary human teeth treated with a conventional brown Sodium Fluoride (5% NaF) Varnish to those treated with a white Fluoride Varnish (5% NaF) enhanced with functionalized tricalcium phosphate (fTCP). Materials and Methods. Ninety extracted caries-free primary incisors were washed in a deter...

Using intact human platelets, we studied the effect of sodium fluoride (NaF) on platelet aggregation and release reaction and correlated the functional changes to intracellular events specific for either agonist-induced or antagonist-induced platelet responses. At lower concentrations, with a peak activity between 30 and 40 mmol/L, NaF induced aggregation and release of adenosine 5'-triphosphat...

The oxidations of organic compounds by permanganate under solvent free conditions have been studied. Thiols and primary aromatic amines undergo oxidative coupling reactions to give disulfides and diazenes, respectively, sulfides are oxidized to sulfones, primary and secondary alcohols are converted to aldehydes and ketones, 1,4-diols and cyclic ethers give lactones and arenes are oxidized to th...

the synthesis of functionalized 2-oxo-2h-coumarin derivatives has been studied by a one-pot reaction of o-hydroxybenzaldehyde, ethyl 2-bromoacetate and triphenylphosphine in the presence of catalytic amount of triethyl amine in etoac, water or under solvent free conditions. we have found the best results obtained under solvent free condition.

this study introduces a green and efficient method for preparation of biologically-active substituted 4h-pyrans using the one-pot three-component reaction of aromatic aldehydes, dimedone and malononitrile in the presence of cobalt oxide nanoparticles. co3o4 nanoparticles were used as an efficient catalyst for the synthesis of polyhydroquinoline derivatives by the reaction of aromatic aldehydes,...