نتایج جستجو برای: soluplus

تعداد نتایج: 99  

2013
Ritesh A. Fule Tarique S. Meer Ajay R. Sav Purnima D. Amin

This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfactants PEG 400, Lutrol F127, and Lutrol F68 and parameters like mixing temperature, screw rotatin...

Journal: :Molecular pharmaceutics 2016
Shu Li Tao Yu Yiwei Tian Colin P McCoy David S Jones Gavin P Andrews

Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large-scale manufacture. Current literature has primarily focused on the preparation and characterization of novel cocrystals typically containing only ...

2015
Jae-Young Lee Wie-Soo Kang Jingpei Piao In-Soo Yoon Dae-Duk Kim Hyun-Jong Cho

BACKGROUND Soluplus(®) (SP) and D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)-based solid dispersion (SD) formulations were developed by hot-melt extrusion (HME) to improve oral bioavailability of valsartan (VST). METHODS HME process with twin-screw configuration for generating a high shear stress was used to prepare VST SD formulations. The thermodynamic state of the drug and ...

2015
Alireza Homayouni Fatemeh Sadeghi Ali Nokhodchi Jaleh Varshosaz Hadi Afrasiabi Garekani

The present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (CLX) in polyvinyl caprolactame-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus(®) (SOL)) prepared by different techniques. Dispersions of CLX in SOL at different ratios (2:1, 1:1, 1:2, 1:4 and 1:6) were prepared by spray drying, conventional solvent evaporation and melting met...

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