A model based on solubility parameters is proposed to predict the solubility curves of antihelmintic drugs at several temperatures, including aqueous and non-aqueous mixtures. The solubility of the drugs was measured in ethanol-water and ethanol-ethyl acetate mixtures at 15-35 degrees C (mebendazole) and at 25 degrees C (thiabendazole and metronidazole). The solid phases were analyzed by differ...

Holtz, F., Behrens, H., Dingwell, D.B. and Taylor, R.P., 1992. Water solubility in aluminosilicate melts of haplogranite composition at 2 kbar. In: Y. Bottinga, D.B. Dingwell and P. Richet (Guest-Editors), Silicate Melts. Chem. Geol., 96: 289-302. The compositional dependence of H20 solubility was investigated at 2 kbar and 800 °C in haplogranite melts (system SiO2-NaAISi3Os-KA1Si308 or Qz-Ab-O...

Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...

Hydrotropy refers to increasing the water solubility of otherwise poorly soluble compound by the presence of small organic molecules. While it can certainly increase the apparent solubility of a lipophilic drug, the effect of hydrotropy on the drugs' permeation through the intestinal membrane has not been studied. The purpose of this work was to investigate the solubility-permeability interplay...

Introduction Hildebrand Parameters and Basic Polymer Solution Thermodynamics Hansen Solubility Parameters Methods and Problems in the Determination of Partial Solubility Parameters Calculation of the Dispersion Solubility Parameter, δD Calculation of the Polar Solubility Parameter, δP Calculation of the Hydrogen Bonding Solubility Parameter, δH Supplementary Calculations and Procedures Temperat...

Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...

Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limita...

A semi-empirical model is developed for the regression of solid-liquid solubility data with temperature. The model fulfils the required boundary conditions, allowing for robust extrapolation to higher and lower temperatures. The model combines a representation of the solid-state activity which accommodates a temperature-dependent heat capacity difference contribution with a scaled three-paramet...