Glaucoma is a leading cause of irreversible blindness. The most common form of glaucoma is Primary Open Angle Glaucoma (POAG), which affects more than 2 million persons over 40 years of age in the USA alone1. Elevated intraocular pressure (IOP) is the only proven treatable risk factor in multiple forms of glaucoma including POAG2. A number of IOP-lowering agents are therefore used in clinical p...

The first step in mining activities is rock excavation in both mine development and production. Constant pressure for cost reduction and creating an improved/safe work environment for personnel has naturally resulted in increased use of mechanical excavation systems in many mining operations. Also, mechanical excavation and mining is more compatible with automation, meaning possibility of reduc...

the first step in mining activities is rock excavation in both mine development and production. constant pressure for cost reduction and creating an improved/safe work environment for personnel has naturally resulted in increased use of mechanical excavation systems in many mining operations. also, mechanical excavation and mining is more compatible with automation, meaning possibility of reduc...

The accelerated creep plays an important role in the disasters of soft-rock tunnels under high stress. However, most previous studies only involved attenuation and uniform creep. Large deformation soft rock occurred during tunneling process Qianzhou–Sanyangchuan Tunnel, Gusu Province, China. In paper, we developed nonlinear generalized Nishihara rheological model with non-stationary parameter (...

This paper describes application of information granulation theory, on the design of rock engineering flowcharts. Firstly, an overall flowchart, based on information granulation theory has been highlighted. Information granulation theory, in crisp (non-fuzzy) or fuzzy format, can take into account engineering experiences (especially in fuzzy shape-incomplete information or superfluous), or engi...

Spectral ratios between soft soil and reference rock sites are often used to predict the sedimentary site response to earthquakes. However , their relationship with the genuine site-specific amplification function is often unclear. We compare the soil-to-rock spectral ratios between the stations that are 3.3 km apart with the "genuine" response given by the ratios between the surface and 17 and...