Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous preclinical testing before their introduction into the clinical setting. The gold standard in the preclinical assessment and quality control of antivenoms is the neutralization of ...

OBJECTIVES To prepare and evaluate the protective efficacy of immunoglobulin Y (IgY) prepared against local Saudi Cerastes cerastes snake venom. METHODS The study was conducted between October 2009 and October 2011 at the Center of Excellence in Biotechnology Research, King Saud University, Riyadh, Kingdom of Saudi Arabia. The study designed as follow; 4 groups of 8 chickens were immunized in...

For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a promising utilization of these venoms or their co...

Antivenin activity of melanin extracted from black tea (MEBT) was reported for the first time. The antagonistic effect of MEBT was evaluated for Agkistrodon contortrix laticinctus (broadbanded copperhead), Agkistrodon halys blomhoffii (Japanese mamushi), and Crotalus atrox (western diamondback rattlesnake) snake venoms administered i.p. to ICR mice. MEBT was injected i.p. immediately after the ...

HONOURS PROJECTS 2012 (at September 29 2011) Labs/ Supervisor(s) Project Title: ON CAMPUS PROJECTS Venoms & Toxins Labs: Hodgson/Fry Konstantakopoulos/ Hodgson/Isbister  Molecular toxinology of Australia’s lesser known venomous snakes  Profiling Australian and Malaysian snake venoms to guide treatment strategies. VascularBiology & Immunopharmacology Labs: Drummond//Sobey/Lim Kemp-Harper/Drummond

1. Chromatography on silica gel, combined with infrared spectrometry, has been used to analyse mixtures of bile acids. 2. The results obtained by applying this method to an ox bile-salt preparation are described. Methyl lithocholate (methyl 3-hydroxycholanate) (1.8 mg.), methyl deoxycholate (methyl 3:12-dihydroxycholanate) (38 mg.), methyl chenodeoxycholate (methyl 3:7-dihydroxycholanate) (0-6 ...

: The venoms of Tunisian wildlife snakes are complex mixtures containing proteins/ peptides and non-protein molecules. Proteins the most abundant compounds responsible for biological effects venoms. Snake proteins have enzymatic or nonenzymatic activities, which grouped into different families, including C-type lectin proteins, disintegrins (long, medium short disintegrins), Kunitz-type serine ...

Snake envenomation has been estimated to affect 1.8 million people annually with about 94,000 deaths mostly in poor tropical countries. Specific antivenoms are the only rational and effective therapy for these cases. Efforts are being made to produce effective, affordable and sufficient antivenoms for these victims. The immunization process, which has rarely been described in detail, is one ste...

UNLABELLED Snake venoms undergo ontogenetic shifts in biochemical and pharmacological activities. This may be related to variation in venom components associated with the ontogenetic shift in diet. We used the short-tailed pit viper Gloydius brevicaudus that displays ontogenetic shifts in diet to examine whether the species displays a neonate-to-adult transition of snake venomics. Venoms from n...