نتایج جستجو برای: snail2
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Abstract Objectives Notch is a conserved pathway involved in cell-fate determination and homeostasis. Its dysregulation plays role poor prognosis drug resistance breast cancer. Targeting signaling via inhibition of the gamma-secretase complex spotlight modern cancer treatments. Gamma-secretase inhibitors (GSI) have shown successful clinical activity treating cancers, yet possible mechanism rema...
BACKGROUND Epithelial-to-mesenchymal transition (EMT) plays a prominent role in tumorigenesis. Metformin exerts antitumorigenic effects in various cancers. This study investigated the mechanisms of metformin in TGF-β1-induced Epithelial-to-mesenchymal transition (EMT) in cervical carcinoma cells. METHODS cells were cultured with 10 ng/mL TGF-β1 to induce EMT and treated with or without metfor...
Neural crest development involves epithelial-mesenchymal transition (EMT), during which epithelial cells are converted into individual migratory cells. Notably, the same signaling pathways regulate EMT function during both development and tumor metastasis. p53 plays multiple roles in the prevention of tumor development; however, its precise roles during embryogenesis are less clear. We have inv...
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