نتایج جستجو برای: sn38
تعداد نتایج: 174 فیلتر نتایج به سال:
Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear zinc finger DNA-binding protein that is implicated in the repair of DNA damage. Inhibition of PARP-1 through genetic knockouts causes cells to become hypersensitive to various chemotherapeutic agents. We tested the chemopotentiating ability of the PARP-1 inhibitor, CEP-6800, when used in combination with temozolomide (TMZ), irinotecan (camptot...
PURPOSE The pipecolinate derivative VX-710 (biricodar; Incel) is a clinically applicable modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1); we studied its activity against the third multidrug resistance (MDR)-associated drug efflux protein, breast cancer resistance protein (BCRP). EXPERIMENTAL DESIGN VX-710 modulation of uptake, retention, and cytotoxicity of mitoxant...
Downloa pose: Treatment of neuroblastoma is successful in less than half of patients with high-risk disease. titumor activity of a water soluble pegylated SN38 drug conjugate, EZN-2208, was compared with 1 (a prodrug for SN38) in preclinical models of human neuroblastoma. erimental Design: The in vitro cytotoxicity of EZN-2208 was tested by counting trypan blue dye– nnexin V–positive cells, whe...
Download pose: Treatment of neuroblastoma is successful in less than half of patients with high-risk disease. titumor activity of a water soluble pegylated SN38 drug conjugate, EZN-2208, was compared with 1 (a prodrug for SN38) in preclinical models of human neuroblastoma. erimental Design: The in vitro cytotoxicity of EZN-2208 was tested by counting trypan blue dye– nnexin V–positive cells, wh...
Irinotecan is a topoisomerase-I (Top-I) inhibitor used for the treatment of colorectal cancer. DNA demethylating agents, including 5-azacytidine (5-aza), display synergistic antitumor activity with several chemotherapy drugs. 5-Aza may enhance irinotecan cytotoxicity by at least one of the following mechanisms: (a) Top-I promoter demethylation, (b) activation of genes involved in Top-I transcri...
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