نتایج جستجو برای: smarcal1
تعداد نتایج: 96 فیلتر نتایج به سال:
Completion of DNA replication after replication stress depends on PCNA, which undergoes monoubiquitination to stimulate direct bypass of DNA lesions by specialized DNA polymerases or is polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template switching mechanisms. Here we report that the ZRANB3 translocase, a SNF2 family member related to the SIOD disord...
Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency. Using a high-throughput screen, we identified compounds that potentiate readthrough by aminoglycosides at multiple nonsense alleles in yeast. Chemical op...
There has been considerable controversy about the action of heparin on mitosis. Early workers in tissue culture routinely used heparizined plasma without apparent inhibition of growth (2). Later, however, several investigators reported that hepa rin inhibited mitosis either in vitro or in vivo (1, 4, 5, 15), although others found it was not in hibitory (8, 10, 14). A search is being made in our...
Structural Analysis of Replication Protein A Recruitment of the DNA Damage Response Protein SMARCAL1
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