Many significant studies have been conducted and applied to use the potential lipid-based drug delivery system, as it provides a suitable means for controlled release. Lipid-based carriers are efficient and safe hence they can be an attractive candidate for formulation of pharmaceuticals and nutraceutcials [1]. Liposomes are microscopic bilayered and spherical-shaped vesicles containing an inte...

Skin injury is the second most common clinical manifestation in patients with systemic lupus erythematosus (SLE). Estrogen may affect the onset and development of SLE through its receptor. In this study, we investigated the role of estrogen membrane receptor G protein-coupled estrogen receptor 1 (GPER1) in skin injury of SLE. We found that skin injury induced by SLE serum was more severe in fem...

The sebaceous gland is composed of sebaceous gland cells that accumulate intracellular lipid droplets when undergoing differentiation. The extent of lipid droplet formation within the sebaceous gland cells thus represents their differentiation status. On reaching maturity, the sebaceous gland cells are then destroyed and the intracellular lipids are secreted to the skin surface whereby they for...

Skin applications of non-thermal atmospheric pressure plasma (NTAPP) have been at-tracting attention from medical and cosmetic aspects. The reactive species generated sources known to play important roles in the skin. For proper applications, it is essential know how they diffuse into In this study, penetration active NTAPP through a skin model was analyzed by UV absorption spectroscopy. diffus...

This contribution summarises the results from a number of investigations undertaken in the spirit of the Domain Mosaic Model proposed by Forslind in 1994. Atomic Force Microscopy (AFM) studies on the two-dimensional phase behaviour of some stratum corneum lipids revealed phase separation of the lipids in the typical case and the ability of cholesterol to reduce the line tension between phases. ...

The stratum corneum is composed of protein-enriched corneocytes embedded in an intercellular matrix of nonpolar lipids organized as lamellar layers and giving rise to epidermal permeability barrier (EPB). EPB defects have an important role in the pathophysiology of skin diseases such as eczema. The transcriptional control of skin lipid metabolism is poorly understood. We have discovered that mi...

BACKGROUND Celecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib produces serious gastrointestinal side effects. It is a highly lipophilic, poorly soluble drug with oral bioavailability of around 40% (Capsule). Therefore the aim of the present investigation was to assess the sk...

BACKGROUND Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown. Abnormalities in essential fatty acid metabolism, free radical generation, lipid peroxidation, and release of lymphokines have been proposed. OBJECTIVE Our purpos...