BACKGROUND Diabetes is characterized by a nitric oxide deficiency at the wound site. This study investigated whether exogenous nitric oxide supplementation with the nitric oxide donor molsidomine (N-ethoxycarbomyl-3-morpholinyl-sidnonimine) could reverse the impaired healing in diabetes. METHODS Wound healing was studied by creating a dorsal skin incision with subcutaneous polyvinyl alcohol s...

Diabetic mice are characterized by an altered expression pattern of VEGF, and impaired vasculogenesis during healing. We investigated the effects of porcine derived relaxin in diabetes-related wound healing defects in genetically diabetic mice. An incisional wound model was produced on the back of female diabetic C57BL/KsJ-m+/+Lept(db) (db+/db+) mice and their normal littermates (db+/+m). Anima...

Diabetic mice are characterized by a disrupted expression pattern of VEGF (vascular endothelial growth factor), and impaired vasculogenesis during healing. Experimental evidence suggests that RLX (relaxin) can improve several parameters associated with wound healing. Therefore we investigated the effects of porcine-derived RLX in diabetes-related wound-healing defects in genetically diabetic mi...

BACKGROUND Catharanthus roseus L (C. roseus) has been used to treat a wide assortment of diseases including diabetes. The objective of our study was to evaluate the antimicrobial and wound healing activity of the flower extract of Catharanthus in rats. METHODS Wound healing activity was determined in rats, after administration (100 mg kg-1 day-1) of the ethanol extract of C. roseus flower, us...

The prioritization of interaction test suites has received more attention in the field of combinatorial interaction testing, especially when testing resources are limited to allow the part of combinatorial test cases to be executed. Many strategies have been proposed to prioritize interaction test suites according to different evaluation measures. However, most of these strategies may face a ch...

PURPOSE To evaluate the influence of sepsis in the process of wound healing in the abdominal wall. METHODS 40 rats divided into two groups of twenty animals: group of study (E) - septic, and the control group (C) - not septic. The two groups were divided into subgroups of 10 to be killed on the third day (n = 10) or seventh (n = 10) postoperative. Sepsis was induced by ligation and puncture o...

Currently, lattice composite structures have many applications in aerospace industries. The present research analyzed the effect of an external skin consisting of a lattice’s cylindrical shell on the buckling strength of composite materials, both numerically and experimentally. Two classes of specimens, with and without external skins, were fabricated using the filament winding process. To find...

Artificial Neural Networks are information processing systems. Over the past several years, these algorithms have received much attention for their applications in pattern completing, pattern matching and classification and also for their use as a tool in various areas of problem solving. In this work, an Artificial Neural Network model is presented for predicting the tensile properties of co...

The static properties of the multi-chain Frenkel–Kontorova model are studied numerically. In the case of incommensurate structure, the transition by breaking of analyticity appears in each chain. A new hull function h(x), which also shows the transition by breaking of analyticity, is defined. The static friction (depinning force) depends strongly on the strength of the substrate potential, the ...