By mean of heterophase polymerization on the silica gel surface has been made in situ immobilization poly [8-methacroyloxy-quinoline], received new organic-mineral composite material. I...

Hydrogels In article number 2008793, Won Jong Kim and co-workers introduce an injectable in situ polymeric aggregate-embodied hybrid hydrogel (M-NO gel) to achieve nitric oxide (NO)-scavenging sequential drug-release for the combinatorial treatment of rheumatoid arthritis. This novel M-NO gel platform incorporated with a “clickable” NO-cleavable crosslinker is expected prove guideline various N...

Ocular Drug Delivery has been a key challenge and attractive field for the pharmaceutical scientist due to peerless anatomy physiology of eye. Glaucoma, dry eye syndrome, keratitis, endophthalmitis, trachoma, conjunctivitis are just few conditions that can affect In order accomplish efficient ocular treatment within eye, At point action, an appropriate supply active substances must be given sus...

BACKGROUND Artificial lesions produced by different protocols might directly influence the response to different remineralising treatments. This study compared the response of different artificial caries-like enamel lesions to home-care and professional fluoride based-remineralising treatments in situ. METHODS The tested demineralising protocols were methylcellulose- MC gel, polyacrylic acid ...

The objective of this work was to develop an oral mucosal drug delivery system to facilitate the local and systemic delivery of acyclovir for the treatment of oral herpes infection caused by the herpes simplex virus (HSV). An in situ gelling system was used to increase the residence time and thus the bioavailability of acyclovir in oral mucosa. Temperature and pH trigged in situ gel formulation...

The role of iron in two modes of integration into alumina catalysts was studied at 0.39 wt% Fe and tested in trichloroethylene combustion. One modified alumina was synthesized using the sol-gel method with Fe added in situ during hydrolysis; another modification was performed using calcined alumina, prepared using the sol-gel method and impregnated with Fe. Several characterization techniques w...

Background The aim of the study was to develop a sustained ocular delivery of brinzolamide (BLZ) based on gellan gum. Methods The formulations were characterized for clarity, gelling capacity, rheological studies, pH, drug content, and in vitro drug-release behavior. In vivo rabbit eye irritation test was conducted to evaluate irritation of the BLZ gel drug-delivery system. The prepared BLZ f...

The purpose of this study was to develop pluronic-based in situ gelling formulations of metronidazole (MTZ) for treatment of bacterial vaginosis, aimed at prolonging the residence time, controlling drug release, enhancing efficacy, decreasing recurrence, and increasing patient compliance. The in situ gel formulations were prepared using different concentrations of pluronic F-127 (PF-127) alone ...

Tripeptide with redox active chemical entities based smart organogels have been used for in situ formation and stabilization of gold and silver nanoparticles within the supramolecular gel networks and the gold nanoparticles are aligned in arrays along the gel nanofibers of peptide 1-toluene gels.