The intension behind the present work was formulation and evaluation of in situ gel of brimonidine tartrate. Brimonidine tartrate is an antiglaucomic agent which shows rapid precorneal exclusion and reduced ocular bioavailability when given in form of conventional ophthalmic formulations. To avoid this, an attempt has been made to formulate thermosensitive in situ gel of brimonidine tartrate to...

1. Isometric and isotonic contractile parameters of the soleus (SOL) and medial gastrocnemius (MG) muscles of seven adult cats were studied. In addition, architectural characteristics of six contralateral pairs of these ankle extensors were determined. 2. The in situ peak isometric tetanic tension developed by the MG at the Achilles tendon is nearly 5 times (9,846 vs 2,125 g) that of the SOL mu...

BACKGROUND Congestive heart failure (CHF) induces abnormalities in skeletal muscle that are thought to in part explain exercise intolerance. The aim of the present study was to determine whether these changes actually result in contractile or metabolic functional alterations and whether they are muscle type specific. METHODS AND RESULTS With a rat model of CHF (induced by aortic banding), we ...

Background—Congestive heart failure (CHF) induces abnormalities in skeletal muscle that are thought to in part explain exercise intolerance. The aim of the present study was to determine whether these changes actually result in contractile or metabolic functional alterations and whether they are muscle type specific. Methods and Results—With a rat model of CHF (induced by aortic banding), we st...

Sol-gel technology is increasingly being used in coatings for corrosion protection and adhesion improvement. So far, the self-healing concept in sol-gel coatings has only been approached from extrinsic healing perspective (i.e. use of nano and micro carriers of corrosion inhibitors) [1]. Despite the benefits of this approach, the damaged area remains open to ambient environment. The implementat...

Core-shell 12-tungstophosphoric acid/TiO2 (HPW/TiO2) nanoparticles at 10 and 20% of HPW have been synthesized by simple in-situ sol- gel method. Characterization of the samples was carried out by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Fourier transform infrared (FTIR). The X-ray diffraction patterns of as prepared solid samples, indicated characterist...

Female rats (7-8 mo old, n = 40) were randomly placed into the intact control (Int) and ovariectomized control (Ovx) groups. Two weeks after ovariectomy, animals were further divided into intact 2-wk hindlimb unloaded (Int-HU) and ovariectomized hindlimb unloaded (Ovx-HU). We hypothesized that there would be greater hindlimb unloading-related atrophy in Ovx than in Int rats. In situ contractile...

Conventional ophthalmic solutions often eliminate rapidly after administration and can’t provide and maintain an adequate concentration of drug in the precorneal area. This can be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the culde-sac. The present work describes the formulation and evaluation of an ophthalmic...

heteropoly acid promoted nanoparticle of nickel oxide samples were prepared by sol-gel method using heteropoly acids. prepared composite was characterized by xrd, ft-ir and icp technique. in this work, we have reported bromination of phenol, its derivatives and some aromatic compounds. the liquid phase bromination of phenol was performed using heteropoly acids immobilized nanoparticle of nickel...