Various nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (SLNs). Due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. Different strategies have been employed to overcome this problem. In this direction, the present study introduces erodible in-situ forming gel systems as poten...

Calsequestrin (CASQ) is the major component of the sarcoplasmic reticulum (SR) lumen in skeletal and cardiac muscles. This calcium binding protein localizes to the junctional SR (jSR) cisternae where it is responsible for the storage of large amounts of Ca 2+ while it is usually absent, at least in its polymerized form, in the free SR. The retention of CASQ inside the jSR is partly due to its a...

PURPOSE To determine site and time of initiation of expression of the membrane-spanning mucin ASGP (rMuc4) and the goblet cell-specific, gel-forming mucin rMuc5AC by the developing rat ocular surface epithelium. METHODS Newborn Sprague-Dawley rat pups were killed at 1, 7, and 14 days after birth. Adult rats (weight, 200 g) were used as controls. Reverse transcription-polymerase chain reaction...

Objective: To develop in-situ gel formulations of Lornoxicam for sustained release to reduce the dosing frequency in treatment rheumatoid arthritis. Methods: The method ion-sensitive formation was used this study. situ were prepared by varying concentrations sodium alginate as a bio-degradable gel-forming polymer, CaCl2 cross-linking agent, and chitosan, HPMCK4, HPMCK15, guar gum, gellan xantha...

The aim of the study was to improve corneal penetration and bioavailability of ofloxacin (OFX) eye preparations. OFX was incorporated in poly (lactide-co-glycolide) as biodegradable microspheres using oil in oil emulsion solvent evaporation technique. The prepared OFX microspheres were then incorporated in Gelrite(®) in situ gel preparation. In addition, OFX Gelrite-based in situ gel formulatio...