The use of survival time models with non-proportional hazard functions is introduced as a method of studying age of onset effects in family studies. Statistical methods for investigating non-proportionality of the hazard function are described, and the application of these methods is illustrated using data from a family study of depression to investigate transmission of age of onset between pro...

The purpose of this paper was to review the theoretical underpinnings, major concepts, and methods of the typological approach. It was argued that the typological approach offers a systematic, empirically rigorous and reliable way to synthesize the nomothetic variable-centered approach with the idiographic case-centered approach. Recent advances in cluster analysis validation make it a promisin...

More than 20 different leukocyte or tissue antigens can presently be recognized; they belong to one complex system (HL-A) which is, from the genetic point of view, very similar to the H-2 system in the mouse. Another independent system consisting of two antigens has also been well defined, the Group Five system. The methods of defining these antigens, their tissue distri bution, and complex rel...