نتایج جستجو برای: single nucleotide polymorphisms
تعداد نتایج: 989640 فیلتر نتایج به سال:
molecular genetics selection on individual genes is a promising method to genetically improve economically important traits in livestock. the insulin like growth factor-i (igf-i) gene may play important roles in growth of multiple tissues, including muscle cells, cartilage and bone. the objectives of the present study were the estimate the haplotype frequencies of the igf-i gene polymorphisms i...
ABSTRACT Background and Objectives: Non-synonymous single nucleotide polymorphisms are typical genetic variations that may potentially affect the structure or function of expressed proteins, and therefore could be involved in complex disorders. A computational-based analysis has been done to evaluate the phenotypic effect of no...
Background and Objective: Genetic factors greatly impact the response to treatment in patients. Recent studies on rs10853728 single nucleotide polymorphisms in the promoter area, determined the IL-28B gene as a host factor affecting the treatment of hepatitis C infection. The aim of this study was to evaluate this polymorphism among Iranian patients Materials and Methods: This cross-sectiona...
background: the serum concentration of high-density lipoprotein cholesterol (hdl-c) is one of the important heritable risk factors for cardiovascular disease and is a target for therapeutic intervention. in this study, we aimed to evaluate the effects of lecithin cholesterol acyltransferase (lcat) gene polymorphism rs5923 on lcat enzyme activity and serum hdl-c concentration. methods: the study...
Background: Androgens have an anti-proliferative effect on endometrial cells. Human androgen receptor (AR) gene contains two polymorphic short tandem repeats of GGC and CAG, and a single-nucleotide polymorphism on exon 1 that is recognized by the restriction enzyme, StuI. Prior studies have shown that the lengths of the CAG and GGC repeats are inversely and linearly related to AR activity and a...
Background and purpose: Estrogen hormone is a physiological regulator of breast tissue proliferation and changes in its signaling pathways, including the alpha-estrogen receptor, occurs during breast cancer and its progression. Single-nucleotide polymorphisms (SNPs) in genes can lead to differences in cancer susceptibility and response to treatment in different populations. In the present study...
Demand for nonnutritive sweeteners continues to increase due to their ability to provide desirable sweetness with minimal calories. Acesulfame potassium and saccharin are well-studied nonnutritive sweeteners commonly found in food products. Some individuals report aversive sensations from these sweeteners, such as bitter and metallic side tastes. Recent advances in molecular genetics have provi...
the immunoreceptor programmed cell death-1 (pd-1) is a cell surface molecule that is reported to play an important role in the regulation of peripheral tolerance. it has been shown that pd-1 gene is associated with susceptibility to the autoimmune disease systemic lupus erythematosus (sle) in humans. however, there are no reports on the association between this gene and multiple sclerosis (ms)....
Relevance . The etiological agent in the development of persistent lymphocytosis and lymphosarcoma cattle is Bovine leukemia virus Phylogenetic analysis sequenced nucleotide sequences BLV env -gene locus main, but not only, approach to pathogen genotypic classification. Metods aim study was identify single-nucleotide polymorphisms -gene, considered as diagnostically significant for SNP genotypi...
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