We have examined the roles played by the Drosophila neural RNA-binding protein Musashi (MSI) in eye development. MSI expression was observed in the nuclei of all photoreceptor cells (R1-R8). Although a msi loss-of-function mutation resulted in only weak abnormalities in photoreceptor differentiation, we found that the msi eye phenotype was significantly enhanced in a seven in absentia (sina) ba...

MOTIVATION In the analysis of homologous sequences, computation of multiple sequence alignments (MSAs) has become a bottleneck. This is especially troublesome for marker genes like the ribosomal RNA (rRNA) where already millions of sequences are publicly available and individual studies can easily produce hundreds of thousands of new sequences. Methods have been developed to cope with such numb...

Microblog provides the first communication platform for burst event due to the immediacy and interactivity of microblog. In this paper, we research on user-oriented and message-oriented measurements of burst topic in Sina microblog. The measurements and analysis on large-scale Sina microblog data set show that our proposed measurement method can measure the characteristics of user and message p...

BACKGROUND The aim of this study was to assess the responsiveness of the asthma control test (ACT) to detect changes at the initiation of therapy and its utilization in the initiation of asthma treatment. METHODS This study was designed as a randomized clinical trial conducted in a primary care setting. The subjects were asthma patients who had not received controller therapy for at least two...

the theories concerning the issue of the soul are so various in the history of philosophy. the nature of the soul, its originatedness or eternity and quality of its relationship with the body are the most controversial issues in philosophical and theological discussions. ibn sina, as a peripatetic philosopher, in most of his writings, has accepted the aristotle's views on the originatednes...

Recent data demonstrate a structural and functional conservation of factors crucial for the development of the insect and the vertebrate eye. We isolated Xenopus siah-2, a protein with 67% identity to Drosophila sina (seven in absentia) and 85% identity to the mouse and human siah-2 proteins. Sina is required in Drosophila for the R7 photoreceptor cell formation during eye development, because ...

Multimedia contents such as images and videos are widely used in social network sites nowadays. Sina Weibo, a Chinese microblogging service, is one of the first microblog platforms to incorporate multimedia content sharing features. This work provides statistical analysis on how multimedia contents are produced, consumed, and propagated in Sina Weibo. Based on 230 million tweets and 1.8 million...