نتایج جستجو برای: simvastatin

تعداد نتایج: 13002  

Journal: :journal of dental research, dental clinics, dental prospects 0
arezoo jahanbin mostafa abtahi parastoo namdar frazin heravi fatemeh sadeghi hamidreza arab

background. this clinical trial evaluated the effect of simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (gi) and clinical attachment loss (cal). methods. 16 females, 25‒40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. the patients were randomly divided into control and e...

Journal: :bulletin of emergency and trauma 0
mojtaba javaherzadeh ali shekarchizadeh marjan kafaei abass mirafshrieh nariman mosaffa babak sabet shahid beheshti university of medical sceinces-faculty of medicine

objective: to determine the preventive effects of local administration of simvastatin for postoperative intra-abdominal adhesion formation in animal model of rat . methods: in this experimental study, 32 wistar albino rats as the animal model of intra-abdominal adhesion formation were included. adhesions were induced in all the animals via abrasion of the peritoneal and intestinal surface durin...

2012
Bok-Soo Lee Jin Yong Choi Joo Yun Kim Seul Hee Han Jeong Euy Park

BACKGROUND AND OBJECTIVES Since statins and angiotensin receptor blockers are a frequently prescribed combination in patients with atherosclerotic cardiovascular diseases, we tested the interactive effects of simvastatin and losartan on atherosclerosis in apolipoprotein E (apoE)(-/-) mice. MATERIALS AND METHODS Apolipoprotein E(-/-) mice were fed a high-fat, high-cholesterol (HFHC) diet for 1...

Journal: :Stroke 2008
Tomohiro Aoki Hiroharu Kataoka Ryota Ishibashi Kazuhiko Nozaki Nobuo Hashimoto

BACKGROUND AND PURPOSE The pathophysiology of cerebral aneurysms (CAs) is linked to chronic inflammation and degradation of extracellular matrix in vascular walls. Because statins have protective effects on various vascular diseases independent of their lipid-lowering effects, we investigated the effect of simvastatin on CA progression. METHODS CAs were induced in Sprague-Dawley rats with or ...

Journal: :Anticancer research 2009
Simon R Bababeygy Nika V Polevaya Sawsan Youssef Amy Sun Anming Xiong Tiffany Prugpichailers Anand Veeravagu Lewis C Hou Lawrence Steinman Victor Tse

BACKGROUND Statins are thought to have tumorolytic properties, reducing angiogenesis by inhibiting pro-angiogenic factors and inducing apoptosis of mural pericytes within the tumor vascular tree. MATERIALS AND METHODS An orthotopic mouse glioblastoma (GL-26) model was used to investigate the effect of simvastatin on glioblastoma vasculature in vivo. GL-26 cells were implanted into the striatu...

2013
Helen Pullisaar Hanna Tiainen Maria A Landin Ståle P Lyngstadaas Håvard J Haugen Janne E Reseland Esben Østrup

The aim of this study was to develop a three-dimensional porous bone graft material as vehicle for simvastatin delivery and to investigate its effect on primary human osteoblasts from three donors. Highly porous titanium dioxide (TiO2) scaffolds were submerged into simvastatin containing alginate solution. Microstructure of scaffolds, visualized by scanning electron microscopy and micro-compute...

Journal: :physiology and pharmacology 0
vahid khori fatemeh alizadeh sorosh aminosariyeh mona pourabouk mohsen nayebpour aref salehi

introduction: recent evidence has indicated that statins can reduce the incidence of both supraventricular and ventricular arrhythmias with various mechanisms. the primary goal of the present study was to determine direct protective role of simvastatin in modifying concealed conduction and the zone of concealment in a simulated model of atrial fibrillation (af) in an isolated atrioventricular (...

Journal: :jundishapur journal of natural pharmaceutical products 0
heshmatollah shahbazian diabetes research center, health research institute, ahvaz jundishapur university of medical sciences, ahvaz, ir iran afagh atrian diabetes research center, health research institute, ahvaz jundishapur university of medical sciences, ahvaz, ir iran leila yazdanpanah diabetes research center, health research institute, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; diabetes research center, health research institute, ahvaz jundishapur university of medical sciences, postal code: 61357-15794, ahvaz, ir iran. tel/fax: +98-6113369539 gholam reza lashkarara diabetes research center, health research institute, ahvaz jundishapur university of medical sciences, ahvaz, ir iran azita zafar mohtashami diabetes research center, health research institute, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

conclusions end stage renal disease (esrd) have accelerated inflammatory conditions. simvastatin clearly lowers the serum levels of crp and il-6, and the white blood cell count in dialysis patients. administering simvastatin to dialysis patients is safe. results at baseline, each of treatment and control groups had similar characteristics. during the study, the average level of crp decreased in...

2017
Nawal M Al-Rasheed Nouf M Al-Rasheed Iman H Hasan Maha A Al-Amin Hanaa N Al-Ajmi Raeesa A Mohamad Ayman M Mahmoud

Simvastatin is a lipid-lowering agent used to treat hypercholesterolemia and to reduce the risk of heart disease. This study scrutinized the beneficial effects of simvastatin on experimental diabetic cardiomyopathy (DCM), pointing to the role of hyperglycemia-induced oxidative stress and inflammation. Diabetes was induced by intraperitoneal injection of streptozotocin and both control and diabe...

Journal: :World journal of emergency medicine 2014
Hui Fu Qiao-Sheng Wang Qiong Luo Si Tan Hua Su Shi-Lin Tang Zheng-Liang Zhao Li-Ping Huang

BACKGROUND Many studies have showed that apoptosis of endothelial cells plays a curial role in the progress of sepsis. But the role of simvastatin in apoptosis of endothelial cells induced by sepsis is not clear. The present study aimed to investigate the role of simvastatin in apoptosis of endothelial cells induced by sepsis and its mechanism. METHODS Human umbilical vein endothelial cells (...

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