the problem of designing a set of routes with minimum cost to serve a collection of customers with a fleet of vehicles is a fundamental challenge when the number of customers to be dropped or picked up is not known during the planning horizon. the purpose of this paper is to develop a vehicle routing problem (vrp) model that addresses stochastic simultaneous pickup and delivery in the urban pub...

a partial least squares (pls) calibration model was developed for the simultaneous spectrophotometricdetermination of pb (ιι), cu (ιι) and ni (ιι) using xylenol orange as a chromogenic reagent. the parameterscontrolling behavior of the system were investigated and optimum conditions were selected. the calibrationgraphs were linear in the ranges of 0.0–9.091, 0.0–2.719 and 0.0–2.381 ppm for lead...

a simple, accurate and precise hptlc- densitometry method for the simultaneousdetermination of abacavir, lamivudine and zidovudine in pharmaceutical tablet has beendeveloped. separation of tablet components was performed on aluminum backed hptlc plates(silica gel 60 f254 20×20 cm with 0.2 mm thickness, camag, muttenz, switzerland ) usingmethanol : chloroform : acetonitrile (4 : 8 : 3 v/v). good...

Simultaneous analysis of gene expression data and genetic variants is highly interest, especially when the number expressions are both greater than sample size. Association causal genes effective SNPs makes use sparse modeling such sets, important. The high-dimensional instrumental variables models one useful association models, which simultaneous relation with complex traits. From a Bayesian v...

In this paper, Cramér type moderate deviations for the maximum of the periodogram and its studentized version are derived. The results are then applied to a simultaneous testing problem in gene expression time series. It is shown that the level of the simultaneous tests is accurate provided that the number of genes G and the sample size n satisfy G = exp(o(n)).

OBJECTIVE To determine changes in chondrocyte transcription of a range of anabolic, catabolic and signaling genes following simultaneous treatment of cartilage with Insulin-like growth factor-1 (IGF-1) and ramp-and-hold mechanical compression, and compare with effects on biosynthesis. METHODS Explant disks of bovine calf cartilage were slowly compressed (unconfined) over 3-min to their 1mm cu...

BACKGROUND HER2/neu overexpression due to gene amplification is an important factor in breast cancer, modifying the sensitivity to anti-HER2 monoclonal antibody therapy. The clinical significance of HER2 expression in non small cell lung carcinoma (NSCLC) is currently under evaluation. The tumor suppressor gene PTEN negatively regulates the HER2/PI3K/Akt signalling pathway. The purpose of this ...

OBJECTIVES Primary: to compare sequential and simultaneous breast pumping on volume of milk expressed and its fat content. Secondary: to measure the effect of breast massage on milk volume and fat content. DESIGN Sequential randomised controlled trial. SETTING Neonatal intensive care unit, North Staffordshire Hospital NHS Trust. SUBJECTS Data on 36 women were analysed; 19 women used simul...

Mitosis dysregulation is common in cancers. This study explored the nuclear expression patterns and prognostic significance of mitotic regulatory proteins, including Aurora kinases, survivin, and p53, in biliary tract cancer (BTC). Archival tumor samples from 161 BTC patients who underwent surgery were tested for the expression of Aurora-A, Aurora-B, survivin, and p53 by immunohistochemistry. T...