medicinal chemistry depends on many other disciplines ranging from organic chemistry andpharmacology to computational chemistry. typically medicinal chemists use the moststraightforward ways to prepare compounds. the validation of any design project comes from thebiological testing.studies of the binding site of vinblastine by a single cross—linking experiment identified it asbeing between resi...

in this paper, an interval approach is presented to achieve perfect selectivity and maximum sensitivity in distance relay zones, considering uncertainties. for this purpose, first, the uncertainties affecting the settings of the three zones of a distance relay are discussed. then, by using the monte-carlo simulation, the uncertainties are modelled and the impedances seen by the distance relay a...

background: gold nanoparticles (gnps) have been shown as a good radiosensitizer. in combination with radiotherapy, several studies with orthovoltage x-rays have shown considerable dose enhancement effects. this paper reports the dose enhancement factor (def) due to gnps in 18 megavoltage (mv) beams. materials and methods: different geometrical 50-nm gnps configurations at a concentration of 5 m...

background: exposure conditions in ct examinations are quite different from conventional xray. in ct examination higher dose is given to patient in comparison with the dose in other diagnostic examinations. in order to calculate organ effective dose in chest ct, monte carlo simulation has been used in this study. materials and methods: the impact survey data were used to determine the parameter...

introduction: radioiodine therapy is an effective method for treating thyroid cancer carcinoma, but it has some affects on normal tissues, hence dosimetry of vital organs are important to weigh the risks and benefits of this method. the aim of this study is to measure the absorbed doses of important organs by mcnp (monte carlo n particle) simulation and comparing the results of different method...

background: one of the main problems of dedicated iort accelerators is to determine dosimetric characteristics of the electron beams. monte carlo simulation of iort accelerator head and produced beam will be useful to improve the accuracy of beam dosimetry. materials and methods: liac accelerator head was modeled using the beamnrcmonte carlo simulation system. phase-space files were generated a...

Abstract Silicon photomultipliers (SiPMs) replace photomultiplier tubes (PMTs) for the detection of light in many applications, particularly high energy physics and medical imaging. We describe a flexible implementation SiPM model GATE Monte Carlo simulation platform, which is based on noise description proposed by Rosado Hidalgo, an easy effective method to determine instantiate with simple me...