Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the protein and its developmental expression by staining embryos with an antiserum aga...

Development of the Drosophila CNS midline cells is dependent upon the function of the single-minded (sim) gene. Sequence analysis shows that sim is a member of the basic-helix-loop-helix class of transcription factors. Cell fate experiments establish that sim is required for early events in midline cell development, including a synchronized cell division, proper formation of nerve cell precurso...

We have investigated the roles of the single-minded (sim) and rhomboid (rho) genes in generating distinct cell fates in the Drosophila embryonic neuroectoderm. We show that sim functions to repress ventral ectodermal cell fates, as in sim mutants mesectodermal cells adopt the fates of neighboring ventral ectodermal cells and targeted sim expression in P[paired.Gal4]/P[UAS-sim] embryos results i...

BACKGROUND Basiliximab is a chimeric human/mouse monoclonal antibody directed against the alpha chain of the IL-2 receptor, CD25, which has been reported as successfully reducing rejection in adult renal transplant recipients. Reported clinical experience of basiliximab in paediatric renal transplantation is limited. METHODS Using two intravenous doses on day 0 (pre-operatively) and day 4 wit...

a signed graph (marked graph) is an ordered pair $s=(g,sigma)$$(s=(g,mu))$, where $g=(v,e)$ is a graph called the underlyinggraph of $s$ and $sigma:erightarrow{+,-}$$(mu:vrightarrow{+,-})$ is a function. for a graph $g$, $v(g),e(g)$ and $c(g)$ denote its vertex set, edge set and cut-vertexset, respectively. the lict graph $l_{c}(g)$ of a graph $g=(v,e)$is defined as the graph having vertex set ...

Many animals have genetically determined left-right (LR) asymmetry of their internal organs. The midline structure of vertebrate embryos has important roles in LR asymmetric development both as the signaling center for LR asymmetry and as a barrier to inappropriate LR signaling across the midline. However, in invertebrates, the functions of the midline in LR asymmetric development are unknown. ...

Recessive mutations in the SIAMESE (SIM) gene of Arabidopsis thaliana result in multicellular trichomes harboring individual nuclei with a low ploidy level, a phenotype strikingly different from that of wild-type trichomes, which are single cells with a nuclear DNA content of approximately 16C to 32C. These observations suggested that SIM is required to suppress mitosis as part of the switch to...

OBJECTIVES Systematic information management in hospitals demands for a strategic information management plan (SIM plan). As preparing a SIM plan is a considerable challenge we provide a practical guideline that is directly applicable when a SIM plan is going to be prepared. METHODS The guideline recommends a detailed structure of a SIM plan and gives advice about its content and the preparat...

2. Overview of GSM SIM Based Authentication This paper discusses approaches to authenticating users with open platforms, such as notebook PCs, for WLAN access using SIM cards. Using SIM cards to authenticate WLAN access is desirable by wireless operators as this approach minimizes additional infrastructure investments since the existing authentication processes and equipment are re-used. This p...