shigella and escherichia belong to the enterobacteriaceae family which are the cause for most of the diarrheal cases in the world. shigella can cause bacterial dysenteries and shigellosis. one of the most effective proteins for pathogenesis is invasion plasmid antigen c (ipac). other bacteria like enterotoxogenic (etec), enterohemorrhagic (ehec), and e.coli can also cause diarrhea and produce i...

For nearly 100 years serotyping has been the gold standard for the identification of Salmonella serovars. Despite the increasing adoption of DNA-based subtyping approaches, serotype information remains a cornerstone in food safety and public health activities aimed at reducing the burden of salmonellosis. At the same time, recent advances in whole-genome sequencing (WGS) promise to revolutioniz...

Background: The modeling of Biological Regulatory Networks (BRNs) relies on background knowledge, deriving either from literature and/or the analysis of biological observations. However, with the development of high-throughput data, there is a growing need for methods that automatically generate admissible models. Methods: Our research aim is to provide a logical approach to infer BRNs based on...

Huntington’s disease is a rare neurodegenerative and autosomal dominant disorder. HD caused by mutation in the gene coding for huntingtin (Htt). The result production of mutant Htt with an abnormally long polyglutamine repeat that leads to pathological aggregates. Although structure human has been determined, albeit at low resolution, its functions how they are performed largely unknown. Moreov...

T-cell activation through the blockade of PD-1 – PD-L1 interactions is recognised at present as one most promising strategies in cancer treatment and a number antibodies targeting immune checkpoint pathway have been approved after successful clinical trials. However, use suffers from shortcomings including poor tissue tumor penetration, long half-life time, oral bioavailability, expensive produ...

Objective: The purpose of the research was to implement molecular docking simulation investigate anti-inflammatory capability against thioesterase-2, an essential component inflammatory reaction in humans. Methods: After obtaining three-dimensional structures arthritis ligand and thioesterase-2 protein from IUPHAR/BPS Guide PHARMACOLOGY, PUBCHEM, RCSB PDB databases server, ligands with suitable...