How do effector CD4 T cells escape cell death during the contraction of the immune response (IR) remain largely unknown. CD47, through interactions with thrombospondin-1 (TSP-1) and SIRP-α, is implicated in cell death and phagocytosis of malignant cells. Here, we reported a reduction in SIRP-α-Fc binding to effector memory T cells (T(EM)) and in vitro TCR-activated human CD4 T cells that was li...

Seed storage proteins are synthesized as sources of carbon, nitrogen and sulfur for the next generation of plants. Reactive oxygen species serve as second messengers for signal transduction; however, molecular targets of oxidant signaling have not been defined. Here, many researchers showes that ligand–receptor mediated signaling promotes reactive oxygen species– dependent protein carbonylation...

Seed storage proteins are synthesized as sources of carbon, nitrogen and sulfur for the next generation of plants. Reactive oxygen species serve as second messengers for signal transduction; however, molecular targets of oxidant signaling have not been defined. Here, many researchers showes that ligand–receptor mediated signaling promotes reactive oxygen species– dependent protein carbonylation...

a signaling partner (Su et al., 2002). A closely related function for the collectins is recognition and removal of Denver, Colorado 80262 apoptotic cells (Ogden et al., 2001) wherein the collectin family molecules bind via their globular heads to the apoptotic cell surface and mediate ingestion through a Summary unique form of stimulated macropinocytosis induced by interaction of their collagen...

The signal regulatory protein (SIRP) locus encodes a family of paired receptors that mediate both activating and inhibitory signals and is associated with type 1 diabetes (T1D) risk. The NOD mouse model recapitulates multiple features of human T1D and enables mechanistic analysis of the impact of genetic variations on disease. In this study, we identify Sirpa encoding an inhibitory receptor on ...

Background: Radiotherapy is an effective and important therapeutic method for breast cancer, but at the same time it has a radiation-induced bystander effect on normal tissue around the tumor. Repair of double-strand breaks (DSBs) by normal cells can reduce the extent of damage caused by this effect. Caveolin-1 (Cav-1) is an important regulatory molecule in cell signal transduction. However, th...

Snake venom, as a natural biotoxin, is widely present in nature and can act coordination with variety of signal regulatory proteins, playing significant role the regulation tumor cell proliferation, metastasis, invasion, angiogenesis. Malignant tumors have long attracted attention medical community leading cause death humans. In this paper, we focus on reviewing progress snake venom apoptosis, ...

CD47 is a ligand of the inhibitory receptor, signal regulatory protein (SIRP)alpha, and its interaction with SIRPalpha on macrophages prevents phagocytosis of autologous hematopoietic cells. CD47-SIRPalpha signaling also regulates dendritic cell (DC) endocytosis, activation, and maturation. In this study, we show that CD47 expression on donor cells plays an important role in suppression of allo...

In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and lymphocytes in the lungs and other affected tissues. Regulatory receptors expressed on monocytes and macrophages act to suppress cytokine production, and reduced expression of regulatory receptors may thus promote tissue inflammation. The aim ...