Background. Iron status in patients with sickle cell anaemia is a matter of continuing investigation. Objective. This paper aims to determine the serum iron status of under-five, sickle cell anaemia patients. Methods. The study spanned from December 2009 to February 2010 at the Consultant Outpatient Clinics involving 97 HbSS subjects and 97 age- and sex-matched HbAA controls. Biochemical iron s...

AIM There are few studies to be found in the literature on ankle-brachial index in sickle cell disease. The aim of this study was to compare ankle-brachial index of steadystate adult sickle cell anaemia patients with that of normal controls. METHODS A descriptive cross-sectional study of 62 sickle cell anaemia patients and 62 age- and gender-matched normal controls was carried out in the adul...

The disorders associated with the sickle cell trait have not, in the past, been seen very often in Britain because they are largely confined to the Negro race. However, increased immigration from the West Indies, where the trait can be found in about 10% of the Negro population (Tomlinson, 1945), has made the recognition of these diseases more important in this country (Diamond, 1959). The sick...

Studies of splenic function were carried out on patients with sickle-cell diseases by the measurement of the clearance of autologous heat-damaged 99mTc-labelled erythrocytes from circulation and into the spleen, the spleen area by a scintillation scanning, the enumeration of pitted erythrocytes by direct-interference microscopy, and the percentage of irreversibly sickled cells (ISC) and of cell...

Inherited hemoglobinopathies led by Sickle Cell Disease (SCD) are key contributors to the anaemia burden in Sub-Saharan Africa (SSA). In Tanzania, an estimated six out of one thousand newborns born with SCD, making Tanzania fourth country highest SCD patients world and third after Nigeria Democratic Republic Congo (DRC) (Nigeria 85,000, 42,000 11,000).

Sickle cell anaemia, often called sickle cell disease or sickle cell disorder, is a term covering a number of similar conditions that affect haemoglobin. It has been described as the most common genetic disorder and affects around 12,500 people in the UK, predominantly of African and Afro-Caribbean descent. The severity of the physical, psychological and social consequences of this cluster of d...

Background: Sickle cell anaemia, a type of haemoglobinopathy is associated with biochemical abnormalities such as imbalance of electrolytes. Aim: To determine and evaluate saliva as a biochemical indicator for electrolyte estimation in sickle cell anaemic patients. Materials and methods: 30 children in the age group of 4-12 years were split into two equal groups: sickle cell anaemia group and c...