More than 30 years ago, Guyton1 described pressurenatriuresis: increasing arterial blood pressure promotes sodium excretion, decreasing blood volume and lowering blood pressure, whereas when blood pressure falls, sodium excretion decreases, and blood volume and blood pressure increase.1,2 The linchpin of the model of Guyton et al3 is the concept of feedback gain. Gain is the degree to which a f...

After centuries of wonder, human being finally realized the decisive possibility of going to the moon a little more than 50 years ago, and in 1969 this became a reality, no longer a dream. The human body, however, is designed to live under 1 g as on Earth. Thus, it is important to understand what happens in the human body under microgravity in order to make rapid progress in space development. ...

Newer techniques that have found a place in cancer management in adults are offered far less commonly in pediatric patients. We present a case of a patient with recurrent Wilms' tumor managed with a novel combination of cytoreductive surgery, intraperitoneal brachytherapy, and subsequent hyperthermic intraperitoneal chemotherapy. Each stage presents challenges that the pediatric anesthetist is ...

One series of half-analogues of Michler’s ketone containing one or more terminal methoxysubstituents with variable tertiary amino groups have been used in this study. NMR spectralresults for the parent ketones confirm earlier findings that ortho proton shifts are apparentlyindependent from steric effects in derivatives of Michler’s ketone because the ring current andcarbonyl-induced shifts are ...

BACKGROUND/AIMS Up to 70% of hemodialysis patients over the age of 54 have relevant cognitive impairment. No standardized protocol for the evaluation and monitoring of this population is available today. We hypothesized that the dialysis procedure and the testing environment induce fluctuations of cognitive performance. METHODS 26 hemodialysis patients were randomly tested using the Montreal ...

Background: We have previously shown that when asthmatics go supine, fluid shifts out of the legs, accumulates in the thorax, and exacerbates lower airway narrowing. In the retrospective analysis of our previous work presented here, we test the hypothesis that the sensitivity of this process relates inversely to baseline caliber of the lower airways. Methods: Eighteen healthy (six women) and si...

We recently engineered encodable lanthanide binding tags (LBTs) into proteins and demonstrated their applicability in Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray crystallography and luminescence studies. Here, we engineered two-loop-LBTs into the model protein interleukin-1β (IL1β) and measured (1)H, (15)N-pseudocontact shifts (PCSs) by NMR spectroscopy. We determined the Δχ-tensors as...

The tumescent technique, developed by dermatologists, has revolutionized the approach to liposuction. It has eliminated concerns about blood loss, fluid replacement and fluid shifts, and the risks and morbidity of general anesthesia. It has also significantly decreased the cost of liposuction by eliminating the need for general anesthesia, an anesthesiologist, a hospital or outpatient operating...

This paper presents a lumped-parameter model that can reproduce blood volume response to fluid infusion. The model represents the fluid shift between the intravascular and interstitial compartments as the output of a hypothetical feedback controller that regulates the ratio between the volume changes in the intravascular and interstitial fluid at a target value (called "target volume ratio"). T...