The predilection of atherosclerotic lesions for specific sites in the arterial tree is believed to be related t o the wall shear stress, exerted by the blood flow. Measurement of the magnitude of the wall shear stress is difficult and is frequently determined by an extrapolation of the velocity field t o find the wall shear rate and an estimation of the viscosity of the fluid in the neighborhoo...

Fluid shear stress alters the morphology and function of the endothelium by activating several kinases. Furthermore, shear stress potently inhibits apoptosis of endothelial cells. Since activation of Akt kinase has been shown to prevent cell death, we investigated the effects of shear stress on Akt phosphorylation. To test the hypothesis that shear stress interacts with the Akt kinase pathway, ...

BACKGROUND Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection. However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies. METHODS AND RESULTS We developed a perivascular shea...

In this study, a realistic model for dynamic instability of embedded single-walled nanotubes (SWCNTs) conveying pulsating fluid is presented considering the viscoelastic property of the nanotubes using Kelvin–Voigt model. SWCNTs are placed in longitudinal magnetic fields and modeled by sinusoidal shear deformation beam theory (SSDBT) as well as modified couple stress theory. The effect of slip ...

OBJECTIVE Laminar shear stress is atheroprotective for endothelial cells (ECs), whereas nonlaminar, disturbed, or oscillatory shear stress correlates with development of atherosclerosis and neointimal hyperplasia. The effects of orbital and laminar shear stress on EC morphology, proliferation, and apoptosis were compared. METHODS ECs were exposed to orbital shear stress with an orbital shaker...

We study rapidly accelerating rupture fronts at the onset of frictional motion by performing high-temporal-resolution measurements of both the real contact area and the strain fields surrounding the propagating rupture tip. We observe large-amplitude and localized shear stress peaks that precede rupture fronts and propagate at the shear-wave speed. These localized stress waves, which retain a w...

Background—Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection. However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies. Methods and Results—We developed a perivascular shear ...

The shear stresses in printed scaffold systems for tissue engineering depend on the flow properties and void volume in the scaffold. In this work, computational fluid dynamics (CFD) is used to simulate flow fields within porous scaffolds used for cell growth. From these models the shear stresses acting on the scaffold fibres are calculated. The results led to the conclusion that the Darcian (k(...

CRACKS in ductile single crystals are analyzed here for geometries and orientations such that twodimensional states of anti-plane shear constitute possible deformation fields. The crystals are modelled as ideally plastic and yield according to critical resolved shear stresses on their slip systems. Restrictions on the asymptotic forms of stress and deformation fields at crack tips are establish...

a 5th order shear deformation theory considering transverse shear deformation effect as well as transverse normal strain deformation effect is presented for static flexure   analysis of simply supported isotropic plate. the assumed displacement field accounts for non-linear variation of in-plane displacements as well as transverse displacement through the plate thickness. the condition of zero ...