Vascular endothelial cell migration is critical in many physiological processes including wound healing and stent endothelialization. To determine how preexisting cell morphology influences cell migration under fluid shear stress, endothelial cells were preset in an elongated morphology on micropatterned substrates, and unidirectional shear stress was applied either parallel or perpendicular to...

This study presents a dynamic-induced direct-shear model to investigate the dynamic triggering of frictional slip on simulated granular gouges. An incident P-wave is generated as a shear load and a normal stress is constantly applied on the gouge layer. The shear stress accumulates in the incident stage and the frictional slip occurs in the slip stage without the effect of the reflected wave. T...

The validity of the flow-mediated dilation test has been questioned due to the lack of normalization to the primary stimulus, shear stress. Shear stress can be calculated using Poiseuille's law. However, little attention has been given to the most appropriate blood velocity parameter(s) for calculating shear stress. The pulsatile nature of blood flow exposes the endothelial cells to two distinc...

The purpose of this study was to determine the influence of radial motion of an arterial wall on the shear stress that flowing blood imposes on the wall (wall shear stress). Wall shear stress is known to influence endothelial cell function and may play a role in atherogenesis, but its magnitude and distribution in the circulation are not well understood. To simulate arterial wall motion, we use...

BACKGROUND In vivo studies have demonstrated that reasonable exercise training can improve endothelial function. To confirm the key role of wall shear stress induced by exercise on endothelial cells, and to understand how wall shear stress affects the structure and the function of endothelial cells, it is crucial to design and fabricate an in vitro multi-component parallel-plate flow chamber sy...

Venous stenosis is a significant problem in arteriovenous fistulae, likely due to anatomical configuration and wall shear stress profiles. To identify linkages between wall shear stress and the magnitude and pattern of vascular stenosis, we produced curved and straight fistulae in a pig model. A complete wall stress profile was calculated for the curved configuration and correlated with luminal...

Many densely packed suspensions and colloids exhibit a behavior known as Discontinuous Shear Thickening in which the shear stress jumps dramatically and reversibly as the shear rate is increased. We performed rheometry and video microscopy measurements on a variety of suspensions to determine the mechanism for this behavior. We distinguish Discontinuous Shear Thickening from inertial effects by...

in this paper, a general solution for torsion of hollow cylinders made of functionally graded materials (fgm) was investigated. the problem was formulated in terms of prandtl’s stress and, in general, the shear stress and angle of twist were derived. variations in the material properties such as young’s modulus and poisson’s ratio might be arbitrary functions of the radial coordinate. various m...

Platelets subjected to elevated levels of fluid shear stress in the absence of exogenous agonists will aggregate. Shear stress-induced aggregation requires von Willebrand factor (vWF) multimers, extracellular calcium (Ca2+), adenosine diphosphate (ADP), and platelet membrane glycoprotein (GP)Ib and GPIIb-IIIa. The sequence of interaction of vWF multimers with platelet surface receptors and the ...

BACKGROUND AND PURPOSE Hemodynamics is often recognized as one of the major factors in aneurysm rupture. Flow impingement, greater pressure, and abnormal wall shear stress are all indications for aneurysm rupture. Characterizing wall shear stress for intracranial aneurysms at similar anatomic locations may help in understanding its role. MATERIALS AND METHODS Twenty-six intracranial aneurysms...