نتایج جستجو برای: shbg

تعداد نتایج: 1178  

2017
Kunhee Han Hyejin Chun Moon-Jong Kim Doo-Yeoun Cho Soo-Hyun Lee Bo Youn Won Kwang-Min Kim Nam-Seok Joo Young-Sang Kim

The association between sex hormone-binding globulin (SHBG) and arterial stiffness in women is not conclusive. In addition, obesity might also be involved in the relationship between SHBG and atherosclerosis. The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. This cross-sectional study included 381 women who ...

Journal: :Human reproduction 2010
S M Veltman-Verhulst T W van Haeften M J C Eijkemans H W de Valk B C J M Fauser A J Goverde

BACKGROUND Low plasma sex hormone-binding globulin (SHBG) concentrations during pregnancy have been associated with the risk of developing gestational diabetes mellitus (GDM). Women presenting with polycystic ovary syndrome (PCOS) often exhibit low plasma SHBG concentration and are at increased risk of developing GDM. In this study, we investigate whether SHBG levels before conception are predi...

Journal: :Reproductive biology 2004
Serge Carreau Sonia Bourguiba Eric Marie

In this study, we have evaluated the hypophyso-gonadal axis in three groups of men aged 60-69, 70-79 and 80-91 years by measuring the intratesticular concentrations of several steroids (pregnenolone, progesterone, DHEA, DHEA-S, testosterone, estradiol) and serum levels of FSH, LH, testosterone, estradiol and sex hormone binding globulin (SHBG). The histological examination of testes revealed no...

2016
Banu Aydın Stephen J. Winters

Sex hormone-binding globulin (SHBG) is a circulating glycoprotein that transports testosterone and other steroids in the blood. Interest in SHBG has escalated in recent years because of its inverse association with obesity and insulin resistance, and because many studies have linked lower circulating levels of SHBG to metabolic syndrome, type 2 diabetes, nonalcoholic fatty liver disease, polycy...

Journal: :Nutrition reviews 2008
Anne-Sophie Morisset Karine Blouin André Tchernof

This review summarizes studies on the effect of various diets on circulating androgen levels and sex hormone-binding globulin (SHBG). Reduced caloric intake leading to significant weight loss increases SHBG levels regardless of diet composition, particularly in women. Cross-sectional studies show that dietary composition is generally not associated with SHBG levels independent of obesity level....

Journal: :Clinical chemistry 1998
J G Lewis P A Elder

To the Editor: Bioavailable testosterone is often derived from the free androgen index (1), which is reliant on measurements of both testosterone and sex hormone-binding globulin (SHBG). Although testosterone assays are widely available in various formats, assays for SHBG are more restricted partly because of the absence of automated procedures and the relatively high expense of kits. Dako (Den...

Journal: :The Journal of clinical endocrinology and metabolism 1999
A Vermeulen L Verdonck J M Kaufman

The free and nonspecifically bound plasma hormone levels generally reflect the clinical situation more accurately than total plasma hormone levels. Hence, it is important to have reliable indexes of these fractions. The apparent free testosterone (T) concentration obtained by equilibrium dialysis (AFTC) as well as the fraction of serum T not precipitated by 50% ammonium sulfate concentration (n...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه مازندران - دانشکده تربیت بدنی علوم ورزشی 1393

هدف: هدف از مطالعه حاضر، بررسی اثر هشت هفته تمرین هوازی بر سطوح پلاسمایی گلبولین متصل شونده به هورمون جنسی(shbg)، تستوسترون و استرادیول در زنان یائسه و غیر یائسه دارای اضافه وزن قبل و بعد از یائسگی است. روش ها: بیست و شش زن مبتلا به اضافه وزن (با شاخص توده بدن(bmi)> kg/m225) به دو گروه غیر یائسه(13=n) و گروه یائسه(13=n) تقسیم شدند. برنامه تمرین هوازی 8 هفته و هر هفته 3 جلسه با شدت 40 تا 80% حد...

Journal: :Cancer research 2006
Yen-Ling Low Alison M Dunning Mitch Dowsett Robert N Luben Kay-Tee Khaw Nick J Wareham Sheila A Bingham

Studies to identify common genetic variants contributing to breast cancer risk often yield inconsistent results. Breast cancer is a complex disease involving both genetic and environmental determinants. Dietary isoflavones are thought to reduce breast cancer risk by stimulating circulating sex hormone-binding globulin (SHBG) levels. The SHBG gene contains a D356N polymorphism and the N variant ...

Journal: :Cell 2006
Thomas E. Willnow Anders Nykjaer

of the 3H-label in their experiments is associated with the cells is difficult to interpret. Although some of the experiments by Hammes et al. are consistent with their “bound steroid” hypothesis (see, for example, Figure 2A), others are not (for example, see Figures 2B and 2C). At a concentration of 1 nM DHT plus 1 nM SHBG, 50% of the steroid exists in the free form. One nanomole of DHTSHBG an...

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