This paper disputes the widely held view that one cannot establish the reliability of a belief-forming process with the use of beliefs that are obtained by that very process since such self-dependent justification is circular. Harold Brown ([1993]) argued in this journal that some cases of self-dependent justification are legitimate despite their circularity. I argue instead that under appropri...

Shal-type (Kv4.x) K(+) channels are expressed in a variety of tissue, with particularly high levels in the brain and heart. These channels are the primary subunits that contribute to transient, voltage-dependent K(+) currents in the nervous system (A currents) and the heart (transient outward current). Recent studies have revealed an enormous degree of complexity in the regulation of these chan...

Four Kv channel-interacting proteins (KChIP1 through KChIP4) interact directly with the N-terminal domain of three Shal-type voltage-gated potassium channels (Kv4.1, Kv4.2, and Kv4.3) to modulate cell surface expression and function of Kv4 channels. Here we report a 2.0 Angstrom crystal structure of the core domain of KChIP1 (KChIP1*) in complex with the N-terminal fragment of Kv4.2 (Kv4.2N30)....

Southwestern Colombia and northern Ecuador were shaken by a shal-low-focus earthquake on 12 December 1979. The magnitude 8 shock, located near Tumaco, Colombia, was the largest in northwestern South America since 1942 and had been forecast to fill a seismic gap. Thrust faulting occurred on a 280- by 130-kilometer rectangular patch of a subduction zone that dips east beneath the Pacific coast of...

Homeostatic control of neural function can be mediated by the regulation of ion channel expression, neurotransmitter receptor abundance, or modulation of presynaptic release. These processes can be implemented through cell autonomous or intercellular signaling. It remains unknown whether different forms of homeostatic regulation can be coordinated to achieve constant neural function. One way to...