1. Three forms of iatrogenic serum enzyme al terat ion are presented, each entailing a different mechanism of action. 2. Recent modifications in creatinine phosphokinase (CPK) assay systems have great ly increased the sensit ivity of this measurement . This increase in sensit ivity has been accompanied by a relative decrease in clinical specificity. In pat ients receiving intramuscular injectio...

The Subacute Toxicity of l,l-Dimethylhydrazine. CORNISH, HERBERT H., and HARTUNG, ROLF (1969). Toxicol. Appl. Pharmacol. 15, 62-68. Daily injections of 70,50,30, or 10 mg UDMH/kg resulted in the death of 9,6, 5, and 0 rats, respectively, in each group of 10. All deaths occurred within the first 3 days. Animals surviving the first 3 days began to gain weight even though daily dosing was continue...

Aim: This study was aimed to evaluate the duration dependent study to develop Plasmodium berghei infection in in vivo system. Methods: 200μl of infected blood containing 1X10 5 parasites was challenged in Swiss mice intraperitoneally for 5, 10 and 15 days. After sacrifice, parasitemia, O2 .generation, NADPH oxidase activity, NO generation of lymphocyte; MDA level, TrxR activity and haemolytic a...

A single dose of CCl4 (1 ml/kg body weight, po in corn oil) increased the levels of SGOT (serum glutamate oxaloacetate transaminase), SGPT (serum glutamate pyruvate transaminase), LDH (lactate dehydrogenase), glutathione-S-transferase and depletion in reduced glutathione, glutathione peroxidase and glutathione reductase. It also caused enhancement in the levels of lipid peroxidation (LPO) and D...

Thirty one children with typhoid fever aged 2 months to 12 years and blood culture positive for multidrug resistant S. typhi were prospectively studied for their hepatic functions at the time of hospitalization and 2-3 weeks after completion of antibiotic therapy. Hepatic manifestations included hepatomegaly (51.6%); jaundice (16.1%); raised levels of serum glutamic oxaloacetic transaminase (SG...

ABSTRAK Minuman beralkohol adalah minuman yang mengandung alkohol dengan kadar berbeda-beda. Penyakit akibat mengonsumsi salah satunya gangguan fungsi hati. Pemeriksaan umum dilakukan untuk mengetahui hati yaitu pengukuran SGOT dan SGPT. Tujuan dari penelitian ini hubungan lama konsumsi SGPT di Desa Kemojing Kecamatan Binangun Kabupaten Cilacap sejumlah 32 orang. Penelitian berjenis observasion...

Indonesia termasuk negara dengan endemisitas sedang sampai tinggi untuk infeksi virus Hepatitis B (VHB). Prevalensi di berdasarkan jenisnya menduduki posisi pertama presentase 21,8%. Penyakit ditandai terjadinya peningkatan kadar SGOT dan SGPT dalam darah karena hati merupakan salah satu organ tubuh yang banyak mengandung enzim transaminase yaitu SGPT. Kegagalan penyebab penurunan trombopoietin...

The usefulness of blood enzyme determinations as markers of liver necrosis was tested in 100 alcoholics who underwent biopsy during clinical investigation. Mean values of glutamate dehydrogenase (GDH), serum aspartate and alanine transferase (SGOT and SGPT), ornithine carbamoyltransferase (OCT), and gamma-glutamyltranspeptidase (gamma-GTP) tended to rise with increasing liver cell necrosis, tho...

Study was undertaken to investigate the various oxidative stress markers and biochemical parameters in anxious rat. Rats were subjected for short (21 days) and long term (up to 84 days) social isolation; the rats displayed an increase in anxiety on elevated plus maze and open field test relative to control. Various markers of oxidative stress like lipid peroxidation (LPO), reduced glutathione (...