نتایج جستجو برای: sfrp
تعداد نتایج: 206 فیلتر نتایج به سال:
Elevated intraocular pressure (IOP) is the principal risk factor for glaucoma and results from excessive impedance of the fluid outflow from the eye. This abnormality likely originates from outflow pathway tissues such as the trabecular meshwork (TM), but the associated molecular etiology is poorly understood. We discovered what we believe to be a novel role for secreted frizzled-related protei...
The present study investigates the force transfer mechanisms for open hoop fiber reinforced plastic (FRP) strips attached at reinforced concrete (R/C) beams with or without anchorage. These open hoop FRP strips are utilized in R/C beams that are in need of shear capacity upgrade. This type of retrofitting is necessary for R/C structures designed with less stringent seismic loading conditions th...
Retina ganglion cell (RGC) axons grow along a stereotyped pathway undergoing coordinated rounds of fasciculation and defasciculation, which are critical to establishing proper eye-brain connections. How this coordination is achieved is poorly understood, but shedding of guidance cues by metalloproteinases is emerging as a relevant mechanism. Secreted Frizzled Related Proteins (Sfrps) are multif...
Animals’ Wnt signaling pathways are highly preserved signal transduction pathways, which play a crucial role in embryogenesis and adult tissue homeostasis. This chapter reviews the three major focusing on some critical proteins Wnt/β-catenin path terms of their evolution act as gateway between extracellular, cytoplasmic, nuclear components to transmit pathways. The Frizzled (FZD) family G-prote...
The telencephalon is one of the most complex parts of the brain, and its patterning is still poorly understood. In this issue of Neuron, describe a novel Wnt antagonist Tlc, a member of the secreted Frizzled-related protein (sFrp) family. Secreted from the anterior boundary of the zebrafish neural plate, Tlc appears to protect the telencephalon from obliteration by a more caudal neural Wnt signal.
Epigenetic silencing of secreted frizzled-related protein (SFRP) genes, antagonists of the WNT pathway, contributes to the pathogenesis of several cancers including non-small cell lung cancer (NSCLC). We hypothesize that methylation analysis of SFRPs family could improve their use as a panel of biomarkers for diagnosing and staging of NSCLC in China. The expression of four SFRP members (SFRP1, ...
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